In the mouse ischaemic myocardium, neutrophils promote ventricular tachycardia via the secretion of resistin-like molecule-γ, according to a new study published in Science.

Large-scale clinical trials presented at the ESC Congress 2025 support the use of high-dose vaccination for influenza to reduce hospitalization for cardiorespiratory disease in older adults and to improve outcomes in patients who have been hospitalized for acute heart failure.

In the dynamic landscape of academic medicine, there is an increased interest in refining the traditional mentoring paradigm to address the many unmet challenges associated with gender disparities within academia. We highlight the need to expand the focus of mentorship to include sponsorship and advocacy, and hope that this shift will foster holistic development in mentees.

Two late-breaking clinical trials presented at the ESC Congress 2025 have explored the efficacy of cardiac myosin inhibitors for the treatment of hypertrophic cardiomyopathy.

In the DIGIT-HF trial, treatment with digitoxin in addition to guideline-directed medical therapy reduced the risk of hospitalization for worsening heart failure or all-cause death compared with placebo in patients with heart failure with reduced ejection fraction.

In patients with uncontrolled or resistant hypertension, the addition of the aldosterone synthase inhibitor baxdrostat to background antihypertensive therapy reduces seated in-office systolic blood pressure after 12 weeks of treatment, according to findings from the BaxHTN trial presented at the ESC Congress 2025.