npj Systems Biology and Applications

npj Systems Biology and Applications

Next generation lineage tracing and its applications to unravel development

Spencer Short
Rodrigo García-Tejera
Daniel L. Coutu

Review 05 June 2025

Featured

Mathematical modeling and mechanisms of HIV latency for personalized anti latency therapies

Gianmarco Rasi
Elena Emili
Paolo Palma
ReviewOpen Access12 Jun 2025
Modeling the use of transient ligand binding information by AMPA receptors

Helena Braunstein
Alejandra C. Ventura
Alejandro Colman-Lerner
ArticleOpen Access01 Jul 2025
Deep exploration of logical models of cell differentiation in human preimplantation embryos

Mathieu Bolteau
Célia Messaoudi
Carito Guziolowski
ArticleOpen Access27 May 2025
Single-cell transcriptomic profiling of immune landscape in triple-negative breast cancer during neoadjuvant chemotherapy

M. R. Patysheva
P. S. Iamshchikov
T. S. Gerashchenko
ArticleOpen Access07 Jul 2025

Announcements

npj Systems Biology and Applications Journal Metrics

npj Systems Biology and Applications has a 2-year impact factor of 3.5 (2024), article downloads of 676,034 (2024) and 4 days from submission to first editorial decision (median) in 2024.
Congratulations to Prof. Réka Albert!

We are excited to share that one of our Associate Editors Prof. Réka Albert (Pennsylvania State University) has been elected to the National Academy of Sciences.
Call for papers: Systems neuroscience

This Collection invites contributions from computational and experimental neuroscience researchers developing new and innovative approaches to understand neuronal function, at different time scales ranging from ECog/EEG to fMRI, and spatial scales ranging from cellular to the whole brain.

Open for submissions
Call for papers: Systems mechanobiology

This Collection invites submissions on interplay of mechanical and molecular cues using diverse experimental tools and computational and theoretical approaches.

Open for submissions

Browse articles

Cellular patterns in Arabidopsis root epidermis emerge from gene regulatory network and diffusion dynamical feedback

Aarón Castillo-Jiménez
Adriana Garay-Arroyo
Elena R. Álvarez-Buylla
ArticleOpen Access01 Oct 2025
On the mechanisms of epidermal stemness and differentiation

Saumya Shukla
Raghvendra Singh
ArticleOpen Access30 Sept 2025
Data-driven inference of Boolean networks from transcriptomes to predict cellular differentiation and reprogramming

Stéphanie Chevalier
Julia Becker
Loïc Paulevé
ArticleOpen Access26 Sept 2025
Integrative structural profiling and ligand optimisation across the transthyretin mutational landscape

Ugo Lomoio
Valentina Carbonari
Pietro Hiram Guzzi
ArticleOpen Access25 Sept 2025
Machine learning and data-driven inverse modeling of metabolomics unveil key processes of active aging

Jiahang Li
Martin Brenner
Wolfram Weckwerth
ArticleOpen Access24 Sept 2025
Leveraging quantitative systems pharmacology modeling for elranatamab regimen optimization in relapsed or refractory multiple myeloma

Kamrine E. Poels
Mohamed Elmeliegy
Blerta Shtylla
ArticleOpen Access01 Sept 2025
Current state and open problems in universal differential equations for systems biology

Maren Philipps
Nina Schmid
Jan Hasenauer
ArticleOpen Access30 Aug 2025
Utility of the continuous spectrum formed by pathological states in characterizing disease properties

Takashi Fujiwara
Yoshiaki Kariya
Tappei Takada
ArticleOpen Access29 Aug 2025
Leveraging agent-based models and deep reinforcement learning to predict taxis in cell migration

Daniel Camacho-Gomez
Raffaele Sentiero
Jose Manuel Garcia-Aznar
ArticleOpen Access26 Aug 2025

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Science jobs

Associate/Full Professor, Neurodevelopment, Wu Tsai Institute and Partner Department(s)

Seeking senior faculty candidates with experience in interdisciplinary understanding of cognition

New Haven, Connecticut

Yale University - Wu Tsai Institute
Director Position, Institute of Molecular Biology, Academia Sinica

The Director is initially appointed for a three-year term, renewable for a second term, and concurrently holds the title of Research Fellow.

128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan

Institute of Molecular Biology, Academia Sinica, Taiwan
Tenure-track Faculty Positions in Metabolism, Immunology and Chemical Biology at the GRC, AS,TW

The Genomics Research Center seeks candidates focused on metabolic sciences, medical biology, or chemical biology to advance disease research.

Taipei (TW)

中研院基因體中心
Tenured/tenure-track professors and outstanding postdoctoral researchers

2024 Excellent Young Scientists Fund (Overseas)

Kunming, Yunnan, China

Institute of Medical Biology Chinese Academy of Medical Sciences (IMBCAMS)
Sincerely invites you to apply for the 2024 Excellent Young Scientists Fund (Overseas) via IMBCAMS

2024 Excellent Young Scientists Fund (Overseas)

Kunming, Yunnan, China

Institute of Medical Biology Chinese Academy of Medical Sciences (IMBCAMS)

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