The authors develop a new computational system for high-throughput mapping of synaptic connectivity using two-photon holographic optogenetics and intracellular recordings.

Using two-photon optogenetics, electrical recordings and sparse signal reconstruction, the authors demonstrate in vivo synaptic connectivity mapping in the mouse visual cortex.

The human brain cycles through a repertoire of brain networks on a 1-second timescale during rest and tasks. This cycling appears to allow periodic engagement of essential cognitive functions, with the speed of cycling linked to genetics and age.

Hachem et al. show that AMPAR signaling drives the acute activation of ependymal-derived neural stem/progenitor cells after spinal cord injury and that this mechanism can be targeted therapeutically to harness the endogenous regenerative potential of the spinal cord.

The face reveals more than just emotion. Cazettes, Reato and colleagues show that subtle facial movements reveal hidden cognitive states, reflecting the brain’s ongoing computations and offering a noninvasive window into unexpressed thoughts and decisions.

Heller et al. showed dense longitudinal imaging in four females, including one with endometriosis and one using oral contraceptives, and the finding that different hormonal milieus influence widespread brain volume changes linked to progesterone or estradiol.

Xu et al. reveal that a bottom-up neural circuit from the medial septum to the subfornical organ prevents overhydration in mice by integrating oral and gastrointestinal signals before osmolality changes, demonstrating precise drinking control mechanisms.

Temporal integration throughout the human auditory cortex is predominantly locked to absolute time and does not vary with the duration of speech structures such as phonemes or words.

Using two-photon optogenetics, electrical recordings and sparse signal reconstruction, the authors demonstrate in vivo synaptic connectivity mapping in the mouse visual cortex.

The authors develop a new computational system for high-throughput mapping of synaptic connectivity using two-photon holographic optogenetics and intracellular recordings.

The promise of genomics-focused neuroscience to improve health outcomes for Indigenous Peoples depends on ensuring more equitable data relationships though culturally appropriate data governance and the technical infrastructure to enable its implementation. Although ethical frameworks and legal policy mechanisms affirm Indigenous rights, there is a persistent gap in translating these commitments into practice. Here we discuss how embedding Indigenous data governance across research infrastructures and data ecosystems is needed to strengthen the field’s capacity to deliver beneficial outcomes for all.

Researchers’ access to scientific research findings remains inequitable owing to financial and geographical barriers, highlighting the need for more sustainable and inclusive modes of communication to complement existing journals and conferences. Free, online webinar platforms offer a powerful way to democratize scientific knowledge and support career development globally. Drawing from our experience building Open Box Science — a not-for-profit grassroots organization that has hosted over 250 webinars for audiences from more than 70 countries — and examining other successful initiatives, we share practical insights on how to build thriving communities for scientific exchange and call for the continuous support of such platforms. We also highlight how early-career scientists can leverage such platforms to expand their network and enrich their perspectives.