Collection 

Mechanisms and impact of 3D genome organisation

Submission status
Open
Submission deadline

The organisation of the genome in three-dimensional space is a fundamental aspect of gene expression programmes that underlie cell fate and plasticity. Understanding 3D genome organisation is essential, as it influences not only normal cellular processes but also the mechanisms behind various diseases, including cancer. Recent technological breakthroughs in genome-wide mapping of chromatin contacts and advances in imaging technologies allow for the exploration of chromosome conformation and nuclear architecture. A pivotal advancement was the introduction of chromosome conformation capture (3C), which paved the way for high-throughput sequencing techniques to investigate chromosomal interactions. These techniques have evolved to include various derivatives, such as Hi-C, which provide insights into genome-wide interactions. However, many questions such as how 3D-genome organisation differs among different cell types or connections between 3D genome organisation and disease phenotypes remain to be studied.

This Collection welcomes submissions investigating mechanisms of TAD formation and maintenance, chromatin looping and gene regulation, impact of 3D genome on transcriptional landscapes and high-throughput methods for studying genome organisation.

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3d illustration of the nucleus inside a eukaryotic cell. The nucleus contains the cell's genetic information in the form of DNA (deoxyribonucleic acid). The DNA is complexed with proteins and stored as chromatin. At centre is the nucleolus, which is responsible for producing components of ribosomes, the cell's protein-manufacturing organelles. The nucleus is surrounded by a membrane that has pores to allow the transport of molecules into and out of the nucleus. Surrounding the nucleus is rough endoplasmic reticulum (RER), the site of protein synthesis.

This Collection is open for submissions from all authors – and not by invitation only – on the condition that the manuscripts fall within the scope of the Collection and the participating journals more generally.

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