Acta Pharmacologica Sinica

Structure genomics of SARS-CoV-2 and its Omicron variant

Advancing active compound discovery for novel drug targets: insights from AI-driven approaches

Xing-you Wang
Yang Chen
Xu-tong Li

Article 17 June 2025

Featured

Circular RNA circDhx32 promotes cardiac inflammatory responses in mouse cardiac ischemia-reperfusion injury via binding to FOXO1 competed with AdipoR1

Wei Si
Chun-lei Wang
Yu Bian
ArticleOpen Access17 Jun 2025
Targeting PPARα activation sensitizes glioblastoma cells to temozolomide and reverses acquired resistance by inhibiting H3K18 lactylation

Zhen-chuan Wang
Chen Li
Peng-fei Ge
Article11 Jun 2025
An update for AlphaFold3 versus experimental structures: assessing the precision of small molecule binding in GPCRs

Shi-yi Shen
Jun-rui Li
Xin-heng He
Article09 Jul 2025
SAAINT-DB: a comprehensive structural antibody database for antibody modeling and design

Xiaoqiang Huang
Jun Zhou
Jie Xu
ArticleOpen Access30 Jun 2025

Current issue

Immune cells in systemic lupus erythematosus: biology and traditional Chinese medicine therapy

Ya-nan Liang
Luo Chen
Yan You
Review Article17 Apr 2025
PRL-3: unveiling a new horizon in cancer therapy

Zi-tong Cao
Jia-luo Mao
Jia Li
Review Article08 May 2025
OTUD1 positively regulates microglia neuroinflammation and promotes the pathogenesis of Alzheimer’s disease by deubiquitinating C/EBPβ

Ling-yu She
Lu-yao Li
Guang Liang
Article07 May 2025
Dysfunction of subthalamic dopaminergic circuitry contributes to anxiety- and depression-like behaviors in 6-OHDA lesion-induced hemiparkinsonian mice

Jia-qi Zhang
Shu-yi Li
Cheng Xiao
Article06 May 2025
Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens

Xiu-ping Fu
Ren-kun Wu
Jay M. Baraban
Article12 May 2025
OTUD1 deficiency attenuates myocardial ischemia/reperfusion induced cardiomyocyte apoptosis by regulating RACK1 phosphorylation

Yue Luo
Wei-xin Li
Wu Luo
Article20 May 2025

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Editorial Excellence

Acta Pharmacologica Sinica, among the top 25% qualifying journals, is recognized for its exceptional editorial excellence, based on data collected from the 2024 Journal Author Satisfaction survey. Congratulations to the Acta Pharmacologica Sinica editors!

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Targeting the interactions between neutrophils and microglia: a novel strategy for anti-inflammatory treatment of stroke

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Zi-yuan Zhao
Ling-lei Kong
Review Article01 Oct 2025
HDAC inhibitor GCJ-490A modulates tumor microenvironment and synergizes with PD-1 antibody against breast and lung cancers in syngeneic murine models

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Ting He
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PXR ribosylation at E194 amplifies NAPQI in acetaminophen‒induced liver injury in mice, rescued by Schisandrin B

Jia-chan Long
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A phase III clinical trial of monthly minodronate in the treatment of Chinese postmenopausal women with osteoporosis

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Article01 Oct 2025
Harnessing deep statistical potential for biophysical scoring of protein-peptide interactions

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Discovery and characterization of a novel HIF-2α agonist for the treatment of CKD-related renal anemia

Shu-qing Chu
Yi-jie Chen
Su-lin Zhang
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ROS-induced degradation of hERG potassium channels contributes to aripiprazole-induced prolongation of the QTc interval

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HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis

Christian D. Mitchell
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Article29 Sept 2025
TNFSF15 alleviates myeloid-derived suppressor cell-mediated cancer immunosuppression in mice

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Advancing active compound discovery for novel drug targets: insights from AI-driven approaches

Featured

Circular RNA circDhx32 promotes cardiac inflammatory responses in mouse cardiac ischemia-reperfusion injury via binding to FOXO1 competed with AdipoR1

Targeting PPARα activation sensitizes glioblastoma cells to temozolomide and reverses acquired resistance by inhibiting H3K18 lactylation

An update for AlphaFold3 versus experimental structures: assessing the precision of small molecule binding in GPCRs

SAAINT-DB: a comprehensive structural antibody database for antibody modeling and design

Current issue

Immune cells in systemic lupus erythematosus: biology and traditional Chinese medicine therapy

PRL-3: unveiling a new horizon in cancer therapy

OTUD1 positively regulates microglia neuroinflammation and promotes the pathogenesis of Alzheimer’s disease by deubiquitinating C/EBPβ

Dysfunction of subthalamic dopaminergic circuitry contributes to anxiety- and depression-like behaviors in 6-OHDA lesion-induced hemiparkinsonian mice

Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens

OTUD1 deficiency attenuates myocardial ischemia/reperfusion induced cardiomyocyte apoptosis by regulating RACK1 phosphorylation

Announcements

Editorial Excellence

Browse articles

Targeting the interactions between neutrophils and microglia: a novel strategy for anti-inflammatory treatment of stroke

HDAC inhibitor GCJ-490A modulates tumor microenvironment and synergizes with PD-1 antibody against breast and lung cancers in syngeneic murine models

PXR ribosylation at E194 amplifies NAPQI in acetaminophen‒induced liver injury in mice, rescued by Schisandrin B

A phase III clinical trial of monthly minodronate in the treatment of Chinese postmenopausal women with osteoporosis

Harnessing deep statistical potential for biophysical scoring of protein-peptide interactions

Discovery and characterization of a novel HIF-2α agonist for the treatment of CKD-related renal anemia

ROS-induced degradation of hERG potassium channels contributes to aripiprazole-induced prolongation of the QTc interval

HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis

TNFSF15 alleviates myeloid-derived suppressor cell-mediated cancer immunosuppression in mice

Trending - Altmetric

Science jobs

Associate/Full Professor, Neurodevelopment, Wu Tsai Institute and Partner Department(s)

Tenure- Track Assistant or Associate Professor

Tenure-Track Faculty Recruitment at the SiRIUS Institute of Medical Research

Faculty Positions in Immune Engineering and Cellular Therapies

Assistant Professor, Research

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Rare adipose disorders (RADs) masquerading as obesity

Cardiorenal syndrome: clinical diagnosis, molecular mechanisms and therapeutic strategies

Kelch-like proteins in the gastrointestinal tumors

TNFSF15 alleviates myeloid-derived suppressor cell-mediated cancer immunosuppression in mice

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