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Prevalence and incidence of epilepsy: A systematic review and meta-analysis of international studies.

Fiest KM, Sauro KM, Wiebe S, Patten SB, Kwon CS, Dykeman J, Pringsheim T, Lorenzetti DL, Jetté N. Fiest KM, et al. Neurology. 2017 Jan 17;88(3):296-303. doi: 10.1212/WNL.0000000000003509. Epub 2016 Dec 16. Neurology. 2017. PMID: 27986877 Free PMC article.

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Psychosis in Alzheimer disease - mechanisms, genetics and therapeutic opportunities.

Ismail Z, Creese B, Aarsland D, Kales HC, Lyketsos CG, Sweet RA, Ballard C. Ismail Z, et al. Nat Rev Neurol. 2022 Mar;18(3):131-144. doi: 10.1038/s41582-021-00597-3. Epub 2022 Jan 4. Nat Rev Neurol. 2022. PMID: 34983978 Free PMC article. Review.

New nosological perspectives have been provided by incorporating the emergence of psychotic symptoms in older adults - even in advance of dementia - into epidemiological and neurobiological frameworks as well as into diagnostic and research criteria such as the International Psyc …

New nosological perspectives have been provided by incorporating the emergence of psychotic symptoms in older adults - even in advance of de …

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Endogenous anticoagulants.

Kubier A, O'Brien M. Kubier A, et al. Top Companion Anim Med. 2012 May;27(2):81-7. doi: 10.1053/j.tcam.2012.07.003. Epub 2012 Sep 12. Top Companion Anim Med. 2012. PMID: 23031460 Review.

Several important endogenous anticoagulants will be discussed in this review including tissue factor pathway inhibitor, antithrombin, protein C, and protein S in origin, structure, mechanism of action, effects of deficiency, and current knowledge in veterinary medic …

Several important endogenous anticoagulants will be discussed in this review including tissue factor pathway inhibitor, antithrombin, protei …

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Point-of-Care Hemoglobin A1c.

O'Brien MJ, Sacks DB. O'Brien MJ, et al. JAMA. 2019 Oct 8;322(14):1404-1405. doi: 10.1001/jama.2019.14063. JAMA. 2019. PMID: 31513231 Free PMC article.

Perform a laboratory-based glucose test to determine the patient's glycemic status. B. Perform a point-of-care (POC) hemoglobin A(1c) (HbA(1c)) test via fingerstick to determine the patient's glycemic status. C. Perform a laboratory-based HbA(1c) test to dete …

Perform a laboratory-based glucose test to determine the patient's glycemic status. B. Perform a point-of-care (POC) hemoglobin A(1c) …

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Exercise training and reproductive outcomes in women with polycystic ovary syndrome: A pilot randomized controlled trial.

Benham JL, Booth JE, Corenblum B, Doucette S, Friedenreich CM, Rabi DM, Sigal RJ. Benham JL, et al. Clin Endocrinol (Oxf). 2021 Aug;95(2):332-343. doi: 10.1111/cen.14452. Epub 2021 May 3. Clin Endocrinol (Oxf). 2021. PMID: 33638879 Free PMC article. Clinical Trial.

Mean waist circumference decreased in all groups (-7.3 cm, -6.9 cm, -4.5 cm in HIIT, CAET and control) with no significant between-group differences. Mean LDL-C was significantly reduced for HIIT compared to CAET (-0.33 mmol/L, p = .03). HDL-C increased in HIIT comp …

Mean waist circumference decreased in all groups (-7.3 cm, -6.9 cm, -4.5 cm in HIIT, CAET and control) with no significant between-group dif …

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Modeling the progression of neuropsychiatric symptoms in Alzheimer's disease with PET-based Braak staging.

Macedo AC, Therriault J, Tissot C, Aumont É, Servaes S, Rahmouni N, Fernandez-Arias J, Lussier FZ, Wang YT, Ng KP, Vermeiren M, Bezgin G, Socualaya KQ, Stevenson J, Hosseini SA, Chamoun M, Ferrari-Souza JP, Ferreira PCL, Bellaver B, Leffa DT, Vitali P, Zimmer ER, Ismail Z, Pascoal TA, Gauthier S, Rosa-Neto P. Macedo AC, et al. Neurobiol Aging. 2024 Dec;144:127-137. doi: 10.1016/j.neurobiolaging.2024.09.009. Epub 2024 Sep 20. Neurobiol Aging. 2024. PMID: 39326302 Free article.

Participants were assigned a Braak stage at baseline and followed for 1.97 (s.d. 0.62) years. NPS were investigated using the Mild Behavioral Impairment Checklist (MBI-C) and the Neuropsychiatric Inventory Questionnaire severity (NPI-Q-S) and distress (NPI-Q- …

Participants were assigned a Braak stage at baseline and followed for 1.97 (s.d. 0.62) years. NPS were investigated using the Mild Be …

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Evaluation of protein C and protein S levels during oral anticoagulant therapy.

O'Brien AE, Tate GM, Shiach C. O'Brien AE, et al. Clin Lab Haematol. 1998 Aug;20(4):245-52. doi: 10.1046/j.1365-2257.1998.00130.x. Clin Lab Haematol. 1998. PMID: 9777272

However, protein S deficiency has not been addressed in this manner. This study compares protein C and protein S by functional and antigenic determination with procoagulant factors of similar half life (Factors VII and II) in an attempt to identify protein …

However, protein S deficiency has not been addressed in this manner. This study compares protein C and protein S by fun …

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NEI's audacious goals initiative.

Salowe RJ, O'Brien JM. Salowe RJ, et al. Ophthalmology. 2014 Mar;121(3):615-6. doi: 10.1016/j.ophtha.2013.11.011. Ophthalmology. 2014. PMID: 24581751 No abstract available.

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Transforming training to reflect the workforce.

Mathur A, Meyers FJ, Chalkley R, O'Brien TC, Fuhrmann CN. Mathur A, et al. Sci Transl Med. 2015 Apr 29;7(285):285ed4. doi: 10.1126/scitranslmed.aaa8200. Sci Transl Med. 2015. PMID: 25925677 Free PMC article. No abstract available.

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Drug-induced mitochondrial toxicity.

Chan K, Truong D, Shangari N, O'Brien PJ. Chan K, et al. Expert Opin Drug Metab Toxicol. 2005 Dec;1(4):655-69. doi: 10.1517/17425255.1.4.655. Expert Opin Drug Metab Toxicol. 2005. PMID: 16863431 Review.

Mitochondria play a critical role in generating most of the cell's energy as ATP. They are also involved in other metabolic processes such as urea generation, haem synthesis and fatty acid beta-oxidation. Disruption of mitochondrial function by drugs can result in cell dea …

Mitochondria play a critical role in generating most of the cell's energy as ATP. They are also involved in other metabolic processes …

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