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Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype.

Maus M, López-Polo V, Mateo L, Lafarga M, Aguilera M, De Lama E, Meyer K, Sola A, Lopez-Martinez C, López-Alonso I, Guasch-Piqueras M, Hernandez-Gonzalez F, Chaib S, Rovira M, Sanchez M, Faner R, Agusti A, Diéguez-Hurtado R, Ortega S, Manonelles A, Engelhardt S, Monteiro F, Stephan-Otto Attolini C, Prats N, Albaiceta G, Cruzado JM, Serrano M. Maus M, et al. Nat Metab. 2023 Dec;5(12):2111-2130. doi: 10.1038/s42255-023-00928-2. Epub 2023 Dec 14. Nat Metab. 2023. PMID: 38097808 Free PMC article.

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Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells.

López-Polo V, Maus M, Zacharioudakis E, Lafarga M, Attolini CS, Marques FDM, Kovatcheva M, Gavathiotis E, Serrano M. López-Polo V, et al. Nat Commun. 2024 Aug 27;15(1):7378. doi: 10.1038/s41467-024-51363-0. Nat Commun. 2024. PMID: 39191740 Free PMC article.

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Cells take a break when they are TIARed.

Altmeyer M. Altmeyer M. EMBO Rep. 2019 Jan;20(1):e47403. doi: 10.15252/embr.201847403. Epub 2018 Dec 11. EMBO Rep. 2019. PMID: 30538115 Free PMC article.

Cell cycle progression relies on controlled transition from one phase of the cell cycle to the next, and sensing whether or not a certain cell cycle phase has been completed before the next phase is allowed to start is crucial for genome integrity and cell survival. In this issue …

Cell cycle progression relies on controlled transition from one phase of the cell cycle to the next, and sensing whether or not a certain ce …

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GRK2-mediated AKT activation controls cell cycle progression and G2 checkpoint in a p53-dependent manner.

Rivas V, González-Muñoz T, Albitre Á, Lafarga V, Delgado-Arévalo C, Mayor F Jr, Penela P. Rivas V, et al. Cell Death Discov. 2024 Aug 29;10(1):385. doi: 10.1038/s41420-024-02143-8. Cell Death Discov. 2024. PMID: 39198399 Free PMC article.

Deciphering the integration of survival pathways with p53-dependent and -independent mechanisms governing the G2/M transition is crucial for understanding G2 arrest functionality and predicting tumor cell response to chemotherapy. ...In cycling cells, but not in G2 checkpo …

Deciphering the integration of survival pathways with p53-dependent and -independent mechanisms governing the G2/M transition is cruc …

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Proximal nerve lesions in early Guillain-Barré syndrome: implications for pathogenesis and disease classification.

Berciano J, Sedano MJ, Pelayo-Negro AL, García A, Orizaola P, Gallardo E, Lafarga M, Berciano MT, Jacobs BC. Berciano J, et al. J Neurol. 2017 Feb;264(2):221-236. doi: 10.1007/s00415-016-8204-2. Epub 2016 Jun 17. J Neurol. 2017. PMID: 27314967 Review.

Early electrophysiology showed either well-defined demyelinating or axonal patterns, or a non-diagnostic pattern with abnormal late responses; there may be attenuated M responses upon lumbar root stimulation as the only finding. Pathological changes predominated in proxima …

Early electrophysiology showed either well-defined demyelinating or axonal patterns, or a non-diagnostic pattern with abnormal late response …

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TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress.

Lafarga V, Sung HM, Haneke K, Roessig L, Pauleau AL, Bruer M, Rodriguez-Acebes S, Lopez-Contreras AJ, Gruss OJ, Erhardt S, Mendez J, Fernandez-Capetillo O, Stoecklin G. Lafarga V, et al. EMBO Rep. 2019 Jan;20(1):e46224. doi: 10.15252/embr.201846224. Epub 2018 Dec 11. EMBO Rep. 2019. PMID: 30538118 Free PMC article.

The G2/M checkpoint coordinates DNA replication with mitosis and thereby prevents chromosome segregation in the presence of unreplicated or damaged DNA Here, we show that the RNA-binding protein TIAR is essential for the G2/M checkpoint and that TIAR accumulates in …

The G2/M checkpoint coordinates DNA replication with mitosis and thereby prevents chromosome segregation in the presence of unreplica …

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Pedaling power and speed production vs. technical factors and track difficulty in bicycle motocross cycling.

Mateo M, Blasco-Lafarga C, Zabala M. Mateo M, et al. J Strength Cond Res. 2011 Dec;25(12):3248-56. doi: 10.1519/JSC.0b013e3181f90847. J Strength Cond Res. 2011. PMID: 21804428

Mateo, M, Blasco-Lafarga, C, and Zabala, M. Pedaling power and speed production vs. technical factors and track difficulty in BMX cycling. ...

Mateo, M, Blasco-Lafarga, C, and Zabala, M. Pedaling power and speed production vs. technical factors and track difficu …

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Increasing the sustainability of photoautotrophic microalgae production by minimising freshwater requirements.

Rivera-Sánchez E, Villaró-Cos S, Salinas-García M, Lafarga T. Rivera-Sánchez E, et al. N Biotechnol. 2025 May 25;86:14-24. doi: 10.1016/j.nbt.2025.01.004. Epub 2025 Jan 15. N Biotechnol. 2025. PMID: 39824244 Free article. Review.

The water requirements for cultivating microalgae are significant, exceeding 1 m(3).kg(-1). This value varies depending on the production strategy. One of the main reasons for water loss is evaporation, which is influenced by the photobioreactor location, the season, and t …

The water requirements for cultivating microalgae are significant, exceeding 1 m(3).kg(-1). This value varies depending on the produc …

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Effect of seawater on the biomass composition of Spirulina produced at a pilot-scale.

Villaró S, García-Vaquero M, Morán L, Álvarez C, Cabral EM, Lafarga T. Villaró S, et al. N Biotechnol. 2023 Dec 25;78:173-179. doi: 10.1016/j.nbt.2023.11.002. Epub 2023 Nov 14. N Biotechnol. 2023. PMID: 37967766 Free article.

The microalga Arthrospira platensis BEA 005B was produced in 11.4 m(3) raceway photobioreactors and a culture medium based on commercial fertilisers and either freshwater or seawater. The biomass productivity of the reactors operated at a fixed dilution rate of 0.3 day(-1) …

The microalga Arthrospira platensis BEA 005B was produced in 11.4 m(3) raceway photobioreactors and a culture medium based on commerc …

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Production of enzymatic hydrolysates with in vitro antioxidant, antihypertensive, and antidiabetic properties from proteins derived from Arthrospira platensis.

Villaró S, Jiménez-Márquez S, Musari E, Bermejo R, Lafarga T. Villaró S, et al. Food Res Int. 2023 Jan;163:112270. doi: 10.1016/j.foodres.2022.112270. Epub 2022 Dec 7. Food Res Int. 2023. PMID: 36596181

The microalga Arthrospira platensis BEA 005B was produced using 80 m(2) (9 m(3)) raceway photobioreactors achieving a biomass productivity of 28.2 g.m(-2).day(-1) when operating the reactors in semi-continuous mode (0.33 day(-1)). ...

The microalga Arthrospira platensis BEA 005B was produced using 80 m(2) (9 m(3)) raceway photobioreactors achieving a biomass …

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