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A phase 2a trial of the IL-33 monoclonal antibody tozorakimab in patients with COPD: FRONTIER-4.
Singh D, Guller P, Reid F, Doffman S, Seppälä U, Psallidas I, Moate R, Smith R, Kiraga J, Jimenez E, Brooks D, Kelly A, Nordenmark LH, Sadiq MW, Caballero LM, Kell C, Belvisi MG, Pandya H. Singh D, et al. Eur Respir J. 2025 Jul 14;66(1):2402231. doi: 10.1183/13993003.02231-2024. Print 2025 Jul. Eur Respir J. 2025. PMID: 40154559 Free PMC article. Clinical Trial.
Harnessing macrophage-drug conjugates for allogeneic cell-based therapy of solid tumors via the TRAIN mechanism.
Taciak B, Bialasek M, Kubiak M, Marszalek I, Gorczak M, Osadchuk O, Kurpiel D, Strzemecki D, Barwik K, Skorzynski M, Nowakowska J, Lipiński W, Kiraga Ł, Brancewicz J, Klopfleisch R, Krzemiński Ł, Gorka E, Smolarska A, Padzinska-Pruszynska I, Siemińska M, Guzek J, Kutner J, Kisiala M, Wozniak K, Parisi G, Piacentini R, Cassetta L, Forrester LM, Bodnar L, Weiss T, Boffi A, Kucharzewska P, Rygiel TP, Krol M. Taciak B, et al. Nat Commun. 2025 Feb 4;16(1):1327. doi: 10.1038/s41467-025-56637-9. Nat Commun. 2025. PMID: 39900573 Free PMC article.