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Discovery and characterization of a pan-betacoronavirus S2-binding antibody.

Johnson NV, Wall SC, Kramer KJ, Holt CM, Periasamy S, Richardson SI, Manamela NP, Suryadevara N, Andreano E, Paciello I, Pierleoni G, Piccini G, Huang Y, Ge P, Allen JD, Uno N, Shiakolas AR, Pilewski KA, Nargi RS, Sutton RE, Abu-Shmais AA, Parks R, Haynes BF, Carnahan RH, Crowe JE Jr, Montomoli E, Rappuoli R, Bukreyev A, Ross TM, Sautto GA, McLellan JS, Georgiev IS. Johnson NV, et al. Among authors: paciello i. Structure. 2024 Nov 7;32(11):1893-1909.e11. doi: 10.1016/j.str.2024.08.022. Epub 2024 Sep 25. Structure. 2024. PMID: 39326419

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Antigenic sin and multiple breakthrough infections drive converging evolution of COVID-19 neutralizing responses.

Paciello I, Pierleoni G, Pantano E, Antonelli G, Pileri P, Maccari G, Cardamone D, Realini G, Perrone F, Neto MM, Pozzessere S, Fabbiani M, Panza F, Rancan I, Tumbarello M, Montagnani F, Medini D, Maes P, Temperton N, Simon-Loriere E, Schwartz O, Rappuoli R, Andreano E. Paciello I, et al. Cell Rep. 2024 Sep 24;43(9):114645. doi: 10.1016/j.celrep.2024.114645. Epub 2024 Aug 27. Cell Rep. 2024. PMID: 39207904 Free PMC article.

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Human monoclonal antibodies targeting subdominant meningococcal antigens confer cross-protection against gonococcus.

Troisi M, Fabbrini M, Stazzoni S, Viviani V, Carboni F, Abbiento V, Fontana LE, Tomei S, Audagnotto M, Santini L, Spagnuolo A, Antonelli G, Paciello I, Vacca F, Cardamone D, Marini E, Mokhtary P, Finetti F, Giusti F, Bodini M, Torricelli G, Limongi C, Del Vecchio M, Favaron S, Tavarini S, Sammicheli C, Rossi A, Mandelli AP, Fortini P, Caffarelli C, Gonnelli S, Nuti R, Efron A, Baldari CT, Sala C, Tagliabue A, Savino S, Brunelli B, Norais N, Frigimelica E, Bardelli M, Pizza M, Margarit I, Delany I, Finco O, Andreano E, Rappuoli R. Troisi M, et al. Among authors: paciello i. Sci Transl Med. 2025 May 21;17(799):eadv0969. doi: 10.1126/scitranslmed.adv0969. Epub 2025 May 21. Sci Transl Med. 2025. PMID: 40397716

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A multifunctional anti-O-Antigen human monoclonal antibody protects against Shigella sonnei infection in vivo.

Ridelfi M, Vezzani G, Roscioli E, Batani G, Boero E, Nannini F, Marini E, Bhaumik U, Desalegn G, Serpino O, Molinaro A, Paciello I, Mugnaini C, De Santi C, Maccari G, De Rosa A, Valensin S, Duatti A, Di Benedetto R, Raso MM, Alfini R, Sammicheli C, Tavarini S, Quigley C, Podda A, Kabanova A, Andreano E, Cardamone D, Gasperini G, Necchi F, Pizza M, Martin LB, Frenck RW Jr, Grassart A, Silipo A, Pasetti MF, Berlanda Scorza F, Giannelli C, Rossi O, Micoli F, Sala C, Rappuoli R. Ridelfi M, et al. Among authors: paciello i. Proc Natl Acad Sci U S A. 2025 Jul 29;122(30):e2426211122. doi: 10.1073/pnas.2426211122. Epub 2025 Jul 23. Proc Natl Acad Sci U S A. 2025. PMID: 40699929 Free PMC article.

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The Orchestra and Its Maestro: Shigella's Fine-Tuning of the Inflammasome Platforms.

Hermansson AK, Paciello I, Bernardini ML. Hermansson AK, et al. Among authors: paciello i. Curr Top Microbiol Immunol. 2016;397:91-115. doi: 10.1007/978-3-319-41171-2_5. Curr Top Microbiol Immunol. 2016. PMID: 27460806 Review.

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Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody.

Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, Montomoli E, Mouquet H, Schwartz O, Sala C, De Francesco R, Wilson IA, Rappuoli R, Ward AB. Torres JL, et al. Among authors: paciello i. Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2120976119. doi: 10.1073/pnas.2120976119. Epub 2022 May 12. Proc Natl Acad Sci U S A. 2022. PMID: 35549549 Free PMC article.

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Extremely potent human monoclonal antibodies from COVID-19 convalescent patients.

Andreano E, Nicastri E, Paciello I, Pileri P, Manganaro N, Piccini G, Manenti A, Pantano E, Kabanova A, Troisi M, Vacca F, Cardamone D, De Santi C, Torres JL, Ozorowski G, Benincasa L, Jang H, Di Genova C, Depau L, Brunetti J, Agrati C, Capobianchi MR, Castilletti C, Emiliozzi A, Fabbiani M, Montagnani F, Bracci L, Sautto G, Ross TM, Montomoli E, Temperton N, Ward AB, Sala C, Ippolito G, Rappuoli R. Andreano E, et al. Among authors: paciello i. Cell. 2021 Apr 1;184(7):1821-1835.e16. doi: 10.1016/j.cell.2021.02.035. Epub 2021 Feb 23. Cell. 2021. PMID: 33667349 Free PMC article.

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SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma.

Andreano E, Piccini G, Licastro D, Casalino L, Johnson NV, Paciello I, Dal Monego S, Pantano E, Manganaro N, Manenti A, Manna R, Casa E, Hyseni I, Benincasa L, Montomoli E, Amaro RE, McLellan JS, Rappuoli R. Andreano E, et al. Among authors: paciello i. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2103154118. doi: 10.1073/pnas.2103154118. Proc Natl Acad Sci U S A. 2021. PMID: 34417349 Free PMC article.

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Anatomy of Omicron BA.1 and BA.2 neutralizing antibodies in COVID-19 mRNA vaccinees.

Andreano E, Paciello I, Marchese S, Donnici L, Pierleoni G, Piccini G, Manganaro N, Pantano E, Abbiento V, Pileri P, Benincasa L, Giglioli G, Leonardi M, Maes P, De Santi C, Sala C, Montomoli E, De Francesco R, Rappuoli R. Andreano E, et al. Among authors: paciello i. Nat Commun. 2022 Jun 13;13(1):3375. doi: 10.1038/s41467-022-31115-8. Nat Commun. 2022. PMID: 35697673 Free PMC article.

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Safety and serum distribution of anti-SARS-CoV-2 monoclonal antibody MAD0004J08 after intramuscular injection.

Lanini S, Milleri S, Andreano E, Nosari S, Paciello I, Piccini G, Gentili A, Phogat A, Hyseni I, Leonardi M, Torelli A, Montomoli E, Paolini A, Frosini A, Antinori A, Nicastri E, Girardi E, Plazzi MM, Ippolito G, Vaia F, Della Cioppa G, Rappuoli R. Lanini S, et al. Among authors: paciello i. Nat Commun. 2022 Apr 27;13(1):2263. doi: 10.1038/s41467-022-29909-x. Nat Commun. 2022. PMID: 35477725 Free PMC article. Clinical Trial.

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