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Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment.

Barkley D, Moncada R, Pour M, Liberman DA, Dryg I, Werba G, Wang W, Baron M, Rao A, Xia B, França GS, Weil A, Delair DF, Hajdu C, Lund AW, Osman I, Yanai I. Barkley D, et al. Among authors: werba g. Nat Genet. 2022 Aug;54(8):1192-1201. doi: 10.1038/s41588-022-01141-9. Epub 2022 Aug 5. Nat Genet. 2022. PMID: 35931863 Free PMC article.

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Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment.

Werba G, Weissinger D, Kawaler EA, Zhao E, Kalfakakou D, Dhara S, Wang L, Lim HB, Oh G, Jing X, Beri N, Khanna L, Gonda T, Oberstein P, Hajdu C, Loomis C, Heguy A, Sherman MH, Lund AW, Welling TH, Dolgalev I, Tsirigos A, Simeone DM. Werba G, et al. Nat Commun. 2023 Feb 13;14(1):797. doi: 10.1038/s41467-023-36296-4. Nat Commun. 2023. PMID: 36781852 Free PMC article.

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The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression.

Pushalkar S, Hundeyin M, Daley D, Zambirinis CP, Kurz E, Mishra A, Mohan N, Aykut B, Usyk M, Torres LE, Werba G, Zhang K, Guo Y, Li Q, Akkad N, Lall S, Wadowski B, Gutierrez J, Kochen Rossi JA, Herzog JW, Diskin B, Torres-Hernandez A, Leinwand J, Wang W, Taunk PS, Savadkar S, Janal M, Saxena A, Li X, Cohen D, Sartor RB, Saxena D, Miller G. Pushalkar S, et al. Among authors: werba g. Cancer Discov. 2018 Apr;8(4):403-416. doi: 10.1158/2159-8290.CD-17-1134. Epub 2018 Mar 22. Cancer Discov. 2018. PMID: 29567829 Free PMC article.

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Blockade of IL1β and PD1 with Combination Chemotherapy Reduces Systemic Myeloid Suppression in Metastatic Pancreatic Cancer with Heterogeneous Effects in the Tumor.

Oberstein PE, Dias Costa A, Kawaler EA, Cardot-Ruffino V, Rahma OE, Beri N, Singh H, Abrams TA, Biller LH, Cleary JM, Enzinger P, Huffman BM, McCleary NJ, Perez KJ, Rubinson DA, Schlechter BL, Surana R, Yurgelun MB, Wang SJ, Remland J, Brais LK, Bollenrucher N, Chang E, Ali LR, Lenehan PJ, Dolgalev I, Werba G, Lima C, Keheler CE, Sullivan KM, Dougan M, Hajdu C, Dajee M, Pelletier MR, Nazeer S, Squires M, Bar-Sagi D, Wolpin BM, Nowak JA, Simeone DM, Dougan SK. Oberstein PE, et al. Among authors: werba g. Cancer Immunol Res. 2024 Sep 3;12(9):1221-1235. doi: 10.1158/2326-6066.CIR-23-1073. Cancer Immunol Res. 2024. PMID: 38990554 Free PMC article. Clinical Trial.

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POLQ inhibition elicits an immune response in homologous recombination-deficient pancreatic adenocarcinoma via cGAS/STING signaling.

Oh G, Wang A, Wang L, Li J, Werba G, Weissinger D, Zhao E, Dhara S, Hernandez RE, Ackermann A, Porcella S, Kalfakakou D, Dolgalev I, Kawaler E, Golan T, Welling TH, Sfeir A, Simeone DM. Oh G, et al. Among authors: werba g. J Clin Invest. 2023 Jun 1;133(11):e165934. doi: 10.1172/JCI165934. J Clin Invest. 2023. PMID: 36976649 Free PMC article.

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Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance.

Daley D, Mani VR, Mohan N, Akkad N, Ochi A, Heindel DW, Lee KB, Zambirinis CP, Pandian GSB, Savadkar S, Torres-Hernandez A, Nayak S, Wang D, Hundeyin M, Diskin B, Aykut B, Werba G, Barilla RM, Rodriguez R, Chang S, Gardner L, Mahal LK, Ueberheide B, Miller G. Daley D, et al. Among authors: werba g. Nat Med. 2017 May;23(5):556-567. doi: 10.1038/nm.4314. Epub 2017 Apr 10. Nat Med. 2017. PMID: 28394331 Free PMC article.

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The biological underpinnings of therapeutic resistance in pancreatic cancer.

Beatty GL, Werba G, Lyssiotis CA, Simeone DM. Beatty GL, et al. Among authors: werba g. Genes Dev. 2021 Jul 1;35(13-14):940-962. doi: 10.1101/gad.348523.121. Epub 2021 Jun 11. Genes Dev. 2021. PMID: 34117095 Free PMC article. Review.

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Treatment and Management of Peritoneal Spread from Colorectal Cancer Peritoneal Metastasis.

Werba G, Ongchin M. Werba G, et al. Surg Oncol Clin N Am. 2025 Apr;34(2):211-226. doi: 10.1016/j.soc.2024.11.001. Epub 2024 Nov 28. Surg Oncol Clin N Am. 2025. PMID: 40015800 Review.

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Centralized Care of the Surgical Oncology Patient: A Simple Task with Complex Solutions.

Werba G, Zureikat AH. Werba G, et al. Ann Surg Oncol. 2024 Apr;31(4):2190-2191. doi: 10.1245/s10434-023-14881-7. Epub 2024 Jan 15. Ann Surg Oncol. 2024. PMID: 38225479 No abstract available.

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Intrahepatic microbes govern liver immunity by programming NKT cells.

Leinwand JC, Paul B, Chen R, Xu F, Sierra MA, Paluru MM, Nanduri S, Alcantara CG, Shadaloey SA, Yang F, Adam SA, Li Q, Bandel M, Gakhal I, Appiah L, Guo Y, Vardhan M, Flaminio Z, Grodman ER, Mermelstein A, Wang W, Diskin B, Aykut B, Khan M, Werba G, Pushalkar S, McKinstry M, Kluger Z, Park JJ, Hsieh B, Dancel-Manning K, Liang FX, Park JS, Saxena A, Li X, Theise ND, Saxena D, Miller G. Leinwand JC, et al. Among authors: werba g. J Clin Invest. 2022 Apr 15;132(8):e151725. doi: 10.1172/JCI151725. J Clin Invest. 2022. PMID: 35175938 Free PMC article.

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