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Molecular mechanism of ultrafast transport by plasma membrane Ca²⁺-ATPases.

Vinayagam D, Sitsel O, Schulte U, Constantin CE, Oosterheert W, Prumbaum D, Zolles G, Fakler B, Raunser S. Vinayagam D, et al. Among authors: constantin ce. Nature. 2025 Oct;646(8083):236-245. doi: 10.1038/s41586-025-09402-3. Epub 2025 Aug 20. Nature. 2025. PMID: 40836084 Free PMC article.

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Ca²⁺-pumping by PMCA-neuroplastin complexes operates in the kiloHertz-range.

Constantin CE, Schmidt B, Schwarz Y, Harada H, Kollewe A, Müller CS, Henrich S, Gaal B, Kulik A, Bruns D, Schulte U, Rieger H, Fakler B. Constantin CE, et al. Nat Commun. 2025 Aug 20;16(1):7550. doi: 10.1038/s41467-025-62735-5. Nat Commun. 2025. PMID: 40835599 Free PMC article.

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Identification of Cav2-PKCβ and Cav2-NOS1 complexes as entities for ultrafast electrochemical coupling.

Constantin CE, Müller CS, Leitner MG, Bildl W, Schulte U, Oliver D, Fakler B. Constantin CE, et al. Proc Natl Acad Sci U S A. 2017 May 30;114(22):5707-5712. doi: 10.1073/pnas.1616394114. Epub 2017 May 15. Proc Natl Acad Sci U S A. 2017. PMID: 28507132 Free PMC article.

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Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors.

Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, Kuner R. Agarwal N, et al. Among authors: constantin ce. Nat Neurosci. 2007 Jul;10(7):870-9. doi: 10.1038/nn1916. Epub 2007 Jun 10. Nat Neurosci. 2007. PMID: 17558404 Free PMC article.

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Genetic evidence for involvement of neuronally expressed S1P₁ receptor in nociceptor sensitization and inflammatory pain.

Mair N, Benetti C, Andratsch M, Leitner MG, Constantin CE, Camprubí-Robles M, Quarta S, Biasio W, Kuner R, Gibbins IL, Kress M, Haberberger RV. Mair N, et al. Among authors: constantin ce. PLoS One. 2011 Feb 17;6(2):e17268. doi: 10.1371/journal.pone.0017268. PLoS One. 2011. PMID: 21359147 Free PMC article.

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Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity.

Bockhart V, Constantin CE, Häussler A, Wijnvoord N, Kanngiesser M, Myrczek T, Pickert G, Popp L, Sobotzik JM, Pasparakis M, Kuner R, Geisslinger G, Schultz C, Kress M, Tegeder I. Bockhart V, et al. J Neurosci. 2009 Oct 14;29(41):12919-29. doi: 10.1523/JNEUROSCI.1496-09.2009. J Neurosci. 2009. PMID: 19828806 Free PMC article.

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Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization.

Tappe-Theodor A, Constantin CE, Tegeder I, Lechner SG, Langeslag M, Lepcynzsky P, Wirotanseng RI, Kurejova M, Agarwal N, Nagy G, Todd A, Wettschureck N, Offermanns S, Kress M, Lewin GR, Kuner R. Tappe-Theodor A, et al. Among authors: constantin ce. Pain. 2012 Jan;153(1):184-196. doi: 10.1016/j.pain.2011.10.014. Epub 2011 Nov 8. Pain. 2012. PMID: 22071319

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Oncostatin M induces heat hypersensitivity by gp130-dependent sensitization of TRPV1 in sensory neurons.

Langeslag M, Constantin CE, Andratsch M, Quarta S, Mair N, Kress M. Langeslag M, et al. Among authors: constantin ce. Mol Pain. 2011 Dec 23;7:102. doi: 10.1186/1744-8069-7-102. Mol Pain. 2011. PMID: 22196363 Free PMC article.

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Genetic evidence for an essential role of neuronally expressed IL-6 signal transducer gp130 in the induction and maintenance of experimentally induced mechanical hypersensitivity in vivo and in vitro.

Quarta S, Vogl C, Constantin CE, Üçeyler N, Sommer C, Kress M. Quarta S, et al. Among authors: constantin ce. Mol Pain. 2011 Sep 27;7:73. doi: 10.1186/1744-8069-7-73. Mol Pain. 2011. PMID: 21951917 Free PMC article.

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A key role for gp130 expressed on peripheral sensory nerves in pathological pain.

Andratsch M, Mair N, Constantin CE, Scherbakov N, Benetti C, Quarta S, Vogl C, Sailer CA, Uceyler N, Brockhaus J, Martini R, Sommer C, Zeilhofer HU, Müller W, Kuner R, Davis JB, Rose-John S, Kress M. Andratsch M, et al. Among authors: constantin ce. J Neurosci. 2009 Oct 28;29(43):13473-83. doi: 10.1523/JNEUROSCI.1822-09.2009. J Neurosci. 2009. PMID: 19864560 Free PMC article.

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