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Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy.

Saadey AA, Yousif A, Osborne N, Shahinfar R, Chen YL, Laster B, Rajeev M, Bauman P, Webb A, Ghoneim HE. Saadey AA, et al. Among authors: yousif a. Nat Immunol. 2023 Feb;24(2):280-294. doi: 10.1038/s41590-022-01384-y. Epub 2022 Dec 21. Nat Immunol. 2023. PMID: 36543960

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Microglia-targeted inhibition of miR-17 via mannose-coated lipid nanoparticles improves pathology and behavior in a mouse model of Alzheimer's disease.

Badr A, Daily KP, Eltobgy M, Estfanous S, Tan MH, Chun-Tien Kuo J, Whitham O, Carafice C, Gupta G, Amer HM, Shamseldin MM, Yousif A, Deems NP, Fitzgerald J, Yan P, Webb A, Zhang X, Pietrzak M, Ghoneim HE, Dubey P, Barrientos RM, Lee RJ, Kokiko-Cochran ON, Amer AO. Badr A, et al. Among authors: yousif a. Brain Behav Immun. 2024 Jul;119:919-944. doi: 10.1016/j.bbi.2024.05.006. Epub 2024 May 7. Brain Behav Immun. 2024. PMID: 38718909 Free PMC article.

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T cell exhaustion-a memory locked behind scars.

Yousif A, Ghoneim HE. Yousif A, et al. Nat Immunol. 2021 Aug;22(8):938-940. doi: 10.1038/s41590-021-00977-3. Nat Immunol. 2021. PMID: 34312546 No abstract available.

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Chronic ISG15 Exposure Accelerates CD8+ T-cell Dysfunction while Increasing PD-1 Blockade Sensitivity in Oral Squamous Cell Carcinoma.

Chen YL, Yousif A, Chen CH, Lowin A, Saadey AA, Wang SH, Jiang SS, Chen YW, Ghoneim HE. Chen YL, et al. Among authors: yousif a. Cancer Immunol Res. 2025 Aug 29. doi: 10.1158/2326-6066.CIR-25-0047. Online ahead of print. Cancer Immunol Res. 2025. PMID: 40879086

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Faithful Modeling of Terminal CD8 T Cell Dysfunction and Epigenetic Stabilization In Vitro.

Yousif A, Saadey AA, Lowin A, Yousif AM, Saini A, Allison MR, Ptak K, Oltz EM, Ghoneim HE. Yousif A, et al. bioRxiv [Preprint]. 2025 Jun 27:2025.06.22.660847. doi: 10.1101/2025.06.22.660847. bioRxiv. 2025. PMID: 40667348 Free PMC article. Preprint.

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