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C(m)C(a/t)GG methylation: a new epigenetic mark in mammalian DNA?

Lorincz MC, Groudine M. Lorincz MC, et al. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10034-6. doi: 10.1073/pnas.201392598. Proc Natl Acad Sci U S A. 2001. PMID: 11526227 Free PMC article. No abstract available.

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Identification of CDK4 as a target of c-MYC.

Hermeking H, Rago C, Schuhmacher M, Li Q, Barrett JF, Obaya AJ, O'Connell BC, Mateyak MK, Tam W, Kohlhuber F, Dang CV, Sedivy JM, Eick D, Vogelstein B, Kinzler KW. Hermeking H, et al. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2229-34. doi: 10.1073/pnas.050586197. Proc Natl Acad Sci U S A. 2000. PMID: 10688915 Free PMC article.

However, the mechanisms through which c-MYC achieves these effects have been unclear. Using serial analysis of gene expression, we have identified the cyclin-dependent kinase 4 (CDK4) gene as a transcriptional target of c-MYC. c-MYC induced a rapid increase i …

However, the mechanisms through which c-MYC achieves these effects have been unclear. Using serial analysis of gene expression, we ha …

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Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.

Watson ER, Grace CRR, Zhang W, Miller DJ, Davidson IF, Prabu JR, Yu S, Bolhuis DL, Kulko ET, Vollrath R, Haselbach D, Stark H, Peters JM, Brown NG, Sidhu SS, Schulman BA. Watson ER, et al. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17280-17289. doi: 10.1073/pnas.1902889116. Epub 2019 Jul 26. Proc Natl Acad Sci U S A. 2019. PMID: 31350353 Free PMC article.

In addition to covalent thioester linkage to Ub's C terminus for Ub transfer reactions, conjugation enzymes often bind noncovalently and weakly to Ub at "exosites." ...The results provide a tool for probing APC/C activity, have implications for the coordination of K …

In addition to covalent thioester linkage to Ub's C terminus for Ub transfer reactions, conjugation enzymes often bind noncovalently …

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SHORT syndrome with microcephaly and developmental delay.

Patel V, Cui W, Cobben JM. Patel V, et al. Am J Med Genet A. 2023 Mar;191(3):850-854. doi: 10.1002/ajmg.a.63078. Epub 2022 Dec 14. Am J Med Genet A. 2023. PMID: 36515361 Review.

We report a boy with typical clinical features of SHORT syndrome alongside a significant microcephaly and severe developmental delay associated with a de novo single nucleotide missense DNA variant resulting in a single amino acid change in codon 486 of the PIK3R1 gene (PIK3R1 …

We report a boy with typical clinical features of SHORT syndrome alongside a significant microcephaly and severe developmental delay associa …

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Intestinal bile acids provide a surmountable barrier against C. difficile TcdB-induced disease pathogenesis.

Icho S, Ward JS, Tam J, Kociolek LK, Theriot CM, Melnyk RA. Icho S, et al. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2301252120. doi: 10.1073/pnas.2301252120. Epub 2023 May 1. Proc Natl Acad Sci U S A. 2023. PMID: 37126691 Free PMC article.

We show that protection, however, is surmountable and can be overcome at higher doses of TcdB-typical to those seen during severe C. difficile infection-suggesting that the protective properties of intestinal bile acids are operant primarily under low to moderate toxin lev …

We show that protection, however, is surmountable and can be overcome at higher doses of TcdB-typical to those seen during severe C. …

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Dissociative photoionization study of neopentane: a path to an accurate heat of formation of the t-butyl ion, t-butyl iodide, and t-butyl hydroperoxide.

Stevens WR, Walker SH, Shuman NS, Baer T. Stevens WR, et al. J Phys Chem A. 2010 Jan 21;114(2):804-10. doi: 10.1021/jp908583j. J Phys Chem A. 2010. PMID: 19839625

The Delta(f)H degrees (298K)(t-C(4)H(9)(+)) combined with the measured 0 K onsets for t-C(4)H(9)(+) formation from t-butyl iodide (9.170 +/- 0.007 eV) and from t-butyl hydroperoxide (9.904 +/- 0.012 eV), yields 298 K t-butyl iodide …

The Delta(f)H degrees (298K)(t-C(4)H(9)(+)) combined with the measured 0 K onsets for t-C(4)H(9)(+) formation fr …

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Declining greenness in Arctic-boreal lakes.

Kuhn C, Butman D. Kuhn C, et al. Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e2021219118. doi: 10.1073/pnas.2021219118. Proc Natl Acad Sci U S A. 2021. PMID: 33876758 Free PMC article.

The highest concentration of the world's lakes are found in Arctic-boreal regions [C. Verpoorter, T. Kutser, D. A. Seekell, L. J. Tranvik, Geophys. Res. Lett. 41, 6396-6402 (2014)], and consequently are undergoing the most rapid warming [J. ...Here, we analyze time …

The highest concentration of the world's lakes are found in Arctic-boreal regions [C. Verpoorter, T. Kutser, D. A. Seekell, L. …

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Circadian regulation of c-MYC in mice.

Liu Z, Selby CP, Yang Y, Lindsey-Boltz LA, Cao X, Eynullazada K, Sancar A. Liu Z, et al. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21609-21617. doi: 10.1073/pnas.2011225117. Epub 2020 Aug 19. Proc Natl Acad Sci U S A. 2020. PMID: 32817420 Free PMC article.

We find that mutation of both Cry1 and Cry2, which abolishes the negative arm of the clock transcription-translation feedback loop (TTFL), causes down-regulation of c-MYC, and mutation of Bmal1, which abolishes the positive arm of TTFL, causes up-regulation of the c …

We find that mutation of both Cry1 and Cry2, which abolishes the negative arm of the clock transcription-translation feedback loop (TTFL), c …

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Intraoperative Presentation of Malignant Hyperthermia (Confirmed by RYR1 Gene Mutation, c.7522C>T; p.R2508C) Leads to Diagnosis of King-Denborough Syndrome in a Child With Hypotonia and Dysmorphic Features: A Case Report.

Joseph MR, Theroux MC, Mooney JJ, Falitz S, Brandom BW, Byler DL. Joseph MR, et al. A A Case Rep. 2017 Feb 1;8(3):55-57. doi: 10.1213/XAA.0000000000000421. A A Case Rep. 2017. PMID: 27918309

Neurology workup revealed the presence of a known causative ryanodine receptor (RYR1) mutation for MH, c.7522C>T; p.R2508C. Furthermore, the neurology workup diagnosed the child with King-Denborough syndrome (KDS). ...

Neurology workup revealed the presence of a known causative ryanodine receptor (RYR1) mutation for MH, c.7522C>T; p.R2508C. …

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Mechanistic analysis of carbon-carbon bond formation by deoxypodophyllotoxin synthase.

Tang H, Wu MH, Lin HY, Han MR, Tu YH, Yang ZJ, Chien TC, Chan NL, Chang WC. Tang H, et al. Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):e2113770119. doi: 10.1073/pnas.2113770119. Proc Natl Acad Sci U S A. 2022. PMID: 34969844 Free PMC article.

Deoxypodophyllotoxin contains a core of four fused rings (A to D) with three consecutive chiral centers, the last being created by the attachment of a peripheral trimethoxyphenyl ring (E) to ring C. Previous studies have suggested that the iron(II)- and 2-oxoglutarate-depe …

Deoxypodophyllotoxin contains a core of four fused rings (A to D) with three consecutive chiral centers, the last being created by the attac …

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