Pathogenesis articles from across Nature Portfolio

In a combined analysis of two large patient cohorts, three peripheral consensus transcriptomic subtypes of sepsis are identified, which can be linked to an 18-gene classifier associated with different odds of mortality and may offer a way to tailor care for patients with sepsis.

Although DADA2 is typically described as an autosomal recessive disease, it can also present in individuals who are heterozygous for specific ADA2 variants.

In the mouse ischaemic myocardium, neutrophils promote ventricular tachycardia via the secretion of resistin-like molecule-γ, according to a new study published in Science.

Studies of human regulatory genomics are being performed at biobank scales, with data from tens of thousands of individuals. Stephen Montgomery describes how these datasets will advance our understanding of how variation in gene regulation shapes human traits and disease.