Antimicrobial responses articles from across Nature Portfolio

Capsule-specific human monoclonal antibodies are protective against bloodstream infection by Klebsiella pneumoniae sequence type 147 in a mouse model of septicaemia, and could provide a useful strategy against pathogens with antimicrobial resistance.

The immune response involves multiple cell state transitions and complex gene expression changes. Here, the authors establish scIVNL-seq to survey time-resolved RNA dynamics of immune cells during Salmonella infection, revealing distinct RNA control strategies and cell activation patterns underlying immune responses.

Chronic alcohol use in humans and mice downregulates small intestinal mAChR4 and reduces goblet-cell-associated antigen passage formation, disrupting antimicrobial immunity.

A mycovirus drives the fitness of the lung-infecting fungus Aspergillus fumigatus under stress, helping it to survive within immune cells, and thus shaping its pathogenesis.

Giardia intestinalis is a protozoan parasite that can cause severe enteric disease. The immune response to this organism provides unexpected benefits to limit gut inflammation.

A preprint by McCaffrey and Delmastro et al. delineates distinct immunometabolic zones of tuberculosis granulomas and reports that hypoxia is a key driver of immune subversion.

White et al. show that microbiota-specific T cells are licensed by gut inflammation to infiltrate the central nervous system, where cross-reactivity with self-antigens leads to neuropathology.

A preprint by Cheng et al. identifies the proton-activated chloride channel PAC as a negative regulator of phagosomal acidification in macrophages.

The AAA-ATPase, p97, binds ubiquitinated bacterial surface proteins, extracting them with a mechanical force that disrupts and lyses the bacterial cell envelope. Thus, ubiquitination and proteasomal targeting provide cell autonomous immunity against cytosolic intracellular pathogens.