Research articles

In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.

An electrostatic-repulsion-enabled advanced transfer technique based on ammonia solution is introduced for separating van der Waals thin-film materials from their substrates, demonstrating suitability for its use in the complementary metal–oxide–semiconductor (CMOS) industry.

Logical operations can be performed fault-tolerantly with only a constant number of syndrome extraction rounds for a broad class of quantum error correction codes, including the surface code with magic state inputs and feedforward, to achieve ‘transversal algorithmic fault tolerance’.

Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining neuroendocrine–tuft heterogeneity and offering new perspectives for targeting lineage plasticity.

The neuronal architecture that develops after spinal cord injury and causes autonomic dysreflexia is uncovered.

Using SCN2A haploinsufficiency as a proof-of-concept, upregulation of the existing functional gene copy through CRISPR activation was able to rescue neurological-associated phenotypes in Scn2a haploinsufficient mice and human neurons.

A temporal-signal processor based on two in-materia computing hardware platforms—reconfigurable nonlinear-processing units (RNPUs) and analogue in-memory computing (AIMC)—is used for both feature extraction and classification, advancing compactness, efficiency, and performance of heterogeneous smart edge devices.

Repetitive head impacts from contact sports are associated with brain inflammation, vascular damage and neuron loss that are independent of hyperphosphorylated tau pathology.

Engineered prime editor systems with reduced occurrences of unwanted insertions or deletions during genome editing are developed.

Cross-linkable co-SAMs improve hole-selective SAM stability, preventing defects and thermal degredation in perovskite solar cells, enabling 26.92% efficiency with high heat durability, and guiding the design of more efficient and durable solar cells.

Simultaneous recordings were made of hundreds of neurons in the rat frontal cortex and striatum, showing that decision commitment involves a rapid, coordinated transition in dynamical regime and neural mode.

A soft, stretchable and freely movable fibre sensor called NeuroWorm, inspired by earthworms and that can be magnetically steered through soft tissue, is described as a new platform for dynamic bioelectrical and biomechanical monitoring.

A new form of momentum-selective electron energy-loss spectroscopy enables the element-resolved imaging of frequency- and symmetry-dependent vibrational anisotropies with atomic resolution.

The XRISM Resolve spectrum of the galactic neutron star X-ray binary, GX 13+1, reveals one of the densest winds ever seen in absorption lines.

A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.

A study in Drosophila has identified a neural circuit that selectively suppress movement-encoding proprioceptors during self-generated movements such as walking and grooming.