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Alzheimer disease

Timing of hormone replacement therapy could influence Alzheimer disease risk

Nature Reviews Neurology (2025)Cite this article

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The meta-analysis, which was presented by F. N. U. Vaibhav from Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, India, included over 50 clinical trials and observational studies in women with an average age of 51 years. The researchers found that the risk of AD was 32% lower among women who started HRT within 5 years of menopause than in those who received a placebo or no treatment. Conversely, initiation of HRT at ≥65 years of age was linked to a 38% increase in AD risk.

“the risk of AD was 32% lower among women who started HRT within 5 years of menopause”

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References

Original article

  • Vaibhav, F. N. U. et al. Timing-dependent effects of estrogen therapy on Alzheimer’s disease risk in postmenopausal women: a comprehensive meta-analysis (abstract #M219). Ann. Neurol. 98 (Suppl. 34), S258–S259 (2025)

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  • Castro-Aldrete, L. et al. Alzheimer disease seen through the lens of sex and gender. Nat. Rev. Neurol. 21, 235–249 (2025)

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  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Heather Wood

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  1. Heather Wood
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Correspondence to Heather Wood.

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Wood, H. Timing of hormone replacement therapy could influence Alzheimer disease risk. Nat Rev Neurol (2025). https://doi.org/10.1038/s41582-025-01149-9

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