Chan Zuckerberg Initiative

Science is at a pivotal moment, where the intersection of AI and biology has the potential to transform how biological research is done. At CZI, we saw this moment coming. We’ve been working for nearly a decade to build the tools and generate the data sets that are providing the foundation for machine learning to help power this next leap in understanding human health and disease. Now, we’ve identified four scientific grand challenges to move us closer to our goal to cure, prevent and manage all diseases in this century Here’s what we’re focused on: 1️⃣ AI-powered virtual cell models to simulate cell behavior and accelerate discovery 2️⃣ New imaging tools to visualize biology across time and scale 3️⃣ Real-time inflammation sensing to catch disease earlier 4️⃣ Immune engineering to detect and treat conditions before symptoms appear #AIinBiology #ScientificInnovation #ScienceLeadership #science #AI

Cell biology at scale isn’t about doing more experiments; it’s about changing the nature of inquiry. This shift demands scalable platforms, interdisciplinary collaboration, and a rethinking of core biological questions. At #CZBiohubNY we gathered leaders across biology, computation and technology to explore: 🌐Multi-scale biological dynamics 🧠In vivo perturbation technologies 🔬Synthetic organelle design & DNA assembly 🧬Sequence-to-function prediction models 💻Multi-modal data integration and modeling and more #CellBiology #LifeSciences #SyntheticBiology #DataScience #ScientificCollaboration

Happy National Intern Day to the awesome interns making a big impact at CZI! #TeamCZI #NationalInternDay #Community

AI: research assistant or lead scientist? A new Nature study from #CZBiohubSF and Stanford shows the Virtual Lab, where AI agents act like scientists—planning experiments, debating strategies & designing SARS-CoV-2 Nanobodies that actually work in the lab.

“Our strategy is not disease by disease. Our strategy is: how do we make all of science faster.” On the latest episode of Core Memory, our Co-Founder and Co-CEO Priscilla Chan shares how we’re building tools—from single-cell atlases to virtual cell models—to help scientists accelerate their work. She also talks about her path from pediatrician to basic science research, and why AI is a game changer for biology. Listen in: https://lnkd.in/eCyipr2u

🎉 We just took a big step toward early detection, prevention and treatment of disease! 🎉 Inside every cell, genes are making decisions about how to help our bodies function. Our latest AI model, GREmLN, is trained to understand the thousands of decisions those genes make and figure out how things can go wrong. Trained on data from CELLxGENE, a tool to explore standardized single-cell datasets, GREmLN uses the internal logic of cells to gain insights into how they function, including early signs of disease & possible targets for new treatments. We are excited to get our latest AI model into the hands of the scientific community! Learn more on our blog: https://czi.co/4nKowo2 #TransformerModels #LifeScience #AI #SingleCell

CRISPR has transformed what's possible in science. Now, it’s being used to build tailored treatments for children with rare genetic diseases. The new Center for Pediatric CRISPR Cures at University of California, San Francisco and University of California, Berkeley will bring this vision to life, starting with immune and metabolic conditions. With this work—and our continued support through the Rare As One Network—we’re helping accelerate a future of on-demand CRISPR cures. We’re on an ambitious mission to cure, prevent and manage all diseases. More at: http://czi.co/3IwEiCA #RareDisease #CRISPR #Biotech #Science

One word to describe our Summer HQ Week? Magical. Thanks CZIers for your energy and passion. #TeamCZI #Community #Collaboration

“It’s going to be a very powerful tool for understanding what goes wrong in disease,” says Stephen Quake, D.Phil. “Our goal is to create computational tools so that cell biology goes from being 90% experimental and 10% computational to the other way around." https://lnkd.in/gPCBgyiX

Another inspiring Investigator meeting at the CZ Biohub Chicago last week! A highlight was a series of lightning talks by our talented trainees, who showcased their Spark project ideas. These projects, featuring exciting new collaborations among Investigators from the University of Chicago, University of Illinois Urbana-Champaign, & Northwestern University, are launching soon, and we are excited to share more in the coming months. Such incredible energy in the room as we got a first look at these projects. We were also thrilled to welcome a delegate from across the Chan Zuckerberg Initiative and the Chan Zuckerberg Biohub Network - wonderful to have them join us and engage with the exciting work happening in our ecosystem.