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Towards malaria elimination

The launch of a new thematic series of Malaria Journal, "Towards malaria elimination", creates the forum that allows carrying scientific evidence on how to achieve malaria elimination in specific endemic settings and conditions into the circles of scientists, public health specialists, national and global programme managers, funders and decision makers.

"Towards malaria elimination" welcomes original papers, reviews, commentaries and opinion pieces on malaria elimination and eradication, and hopes that this mix of scientific information and debate will catalyze and dynamize the move towards more intensified control and progressively malaria elimination within a spirit of mutual learning for change. The Editors very much hope that many scientists, public health professionals and policy makers will start using "Towards malaria elimination" as one of their ways to share new evidence or to discuss evidence presented in the scientific literature.

View all collections published in Malaria Journal.

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  1. Malaria remains a leading cause of morbidity and mortality among pregnant women and children under five in sub-Saharan Africa. Despite over two decades of efforts including insecticide-treated net (ITN) distri...

    Authors: Denis Okova, Akim Tafadzwa Lukwa, Marian Edusei, Paidamoyo Bodzo, Christian Atta-Obeng, Plaxcedes Chiwire and Charles Hongoro
    Citation: Malaria Journal 2025 24:273
    Content type: Research Published on:

  2. Malaria remains a leading cause of morbidity and mortality in sub-Saharan Africa, particularly among children under five. The introduction of the malaria vaccine presents an opportunity to reduce malaria-relat...

    Authors: Eustes Kigongo, Sean Steven Puleh, Amir Kabunga, Stella Immaculate Akech, Francis Ocen, Marc Sam Opollo and Moses Ebong
    Citation: Malaria Journal 2025 24:259
    Content type: Research Published on:

  3. Assessing vector bionomics and their role in transmission is crucial to improving vector control strategies. Several entomological studies have been conducted to describe malaria transmission in different eco-...

    Authors: Belinda Claire Kiam, Aline Gaelle Bouopda-Tuedom, Jean Arthur Mbida Mbida, Ibrahima Ibrahima, Samuel J. White, Pacome V. K. Tchuenkam, Zachary R. Popkin-Hall, Mariama Mbouh, Charlène Tina Nanssong V., Luc Abate, Clément Janvier Onguene, Brigitte Tumamo Fotso, Jacob M. Sadler, Jonathan B. Parr, Jessica T. Lin, Jonathan J. Juliano…
    Citation: Malaria Journal 2025 24:251
    Content type: Research Published on:

  4. Traditional medicine (TM) has been a cornerstone of healthcare across various cultures, especially in Africa, where it has played an integral role in the management of diseases such as malaria. Despite the pop...

    Authors: Francisca Ogochukwu Onukansi, Collins Chibueze Anokwuru, Stanley Chinedu Eneh, Goodness Ogeyi Odey, Dough Owojoku Onah, Taiwo Sokunbi, David Chinaecherem Innocent, Ugonma Winnie Dozie, Prince Christian Umoke, Temitope Olumuyiwa Ojo and Cosmas Nnadozie Ezejindu
    Citation: Malaria Journal 2025 24:232
    Content type: Perspective Published on:

  5. Malaria remains a significant global health challenge, particularly in sub-Saharan Africa (SSA), where asymptomatic cases contribute to ongoing transmission and hinder elimination efforts. Asymptomatic individ...

    Authors: Wisdom Silwamba, David Chisompola, John Nzobokela, Martin Chakulya, Lombe Kabwe and Kingsley Tembo
    Citation: Malaria Journal 2025 24:221
    Content type: Research Published on:

  7. Vector-borne parasitic infectious diseases, particularly malaria, pose significant challenges to global public health. Understanding the environmental factors influencing the growth and reproduction of malaria...

    Authors: Saideh Yousefi, Omid Dehghan, Madineh Abbasi and Ahmad Ali Hanafi-Bojd
    Citation: Malaria Journal 2025 24:200
    Content type: Research Published on:

  8. Long-lasting insecticidal nets are the primary malaria vector control measure in coastal Kenya. In 2018, phenotypic resistance to pyrethroids and low frequency of L1014S kdr mutation were reported in the Anophele...

    Authors: Miguel Okoko, Jonathan Karisa, Rehema Gona, Tobias Odongo, Bruno Otieno, Festus Yaa, Brian Bartilol, Peter Meli, Zedekiah Ondieki, Mercy Tuwei, Caroline Wanjiku, Faiz Shee, Carlos Chaccour, Caroline Kiuru and Marta F. Maia
    Citation: Malaria Journal 2025 24:191
    Content type: Research Published on:

  9. Malaria remains a critical public health challenge in Nigeria, with the country bearing the highest global burden of the disease. Despite ongoing efforts, malaria continues to exact significant health, economi...

    Authors: Stanley Chinedu Eneh, Chidera Gabriel Obi, Onyeka Chukwudalu Ekwebene, Gabriel Chidera Edeh, Oluwabusayo Awoso, Samson Adiaetok Udoewah, Francisca Ogochukwu Onukansi, Ogechi Vinaprisca Ikhuoria, Ikechukwu Alex Okoli and Temitope Olumuyiwa Ojo
    Citation: Malaria Journal 2025 24:183
    Content type: Perspective Published on:

  10. Plasmodium falciparum histidine-rich protein 2-based rapid diagnostic tests (PfHRP2-based RDTs) are the most widely used malaria RDTs across Africa. The emergence and spread of pfhrp2 gene-deleted parasites have ...

    Authors: Dorcas G. Bredu, Alexander Asamoah, George A. Adu, Bernice C. Abban, Sherik-fa Anang, Nana Y. Peprah, Prosper K. Tey, Sebastian S. Kwapong, Martin Chamai, Eunice O. Amoako, Benjamin Abuaku, Linda E. Amoah and Keziah L. Malm
    Citation: Malaria Journal 2025 24:170
    Content type: Research Published on:

  11. Malaria remains a major public health problem in Cameroon where it accounts for high rates of morbidity and mortality. The management of the disease has been made worst in the North West region of Cameroon and...

    Authors: Joan E. E. Eyong, Calvin B. Ebai, Purity Awah and Antoine S. Kada
    Citation: Malaria Journal 2025 24:161
    Content type: Research Published on:

  12. Malaria continues to pose a public health challenge in Sierra Leone, where timely and accurate forecasting can guide more effective interventions. Although seasonal models such as Seasonal Autoregressive Integ...

    Authors: Saidu Wurie Jalloh, Boniface Malenje, Herbert Imboga and Mary H. Hodges
    Citation: Malaria Journal 2025 24:158
    Content type: Research Published on:

  13. Spatial and temporal identification of malaria-endemic areas is a key component of vector-borne disease control. Strategies to target the most vulnerable populations, the periods of high transmission and the m...

    Authors: Edouard Dangbenon, Mintodê Nicodème Atchadé, Martin C. Akogbéto, Mahouton N. Hounkonnou, Landry Assongba, Hilaire Akpovi, Manisha A. Kulkarni, Natacha Protopopoff, Jackie Cook and Manfred Accrombessi
    Citation: Malaria Journal 2025 24:157
    Content type: Research Published on:

  14. East Africa continues to bear a significant share of the global malaria burden, despite its commitment to the malaria elimination goal of 2030. Furthermore, reported variations in adherence to anti-malarials h...

    Authors: Jackline D. Nkoma, Susan F. Rumisha, Hamisi S. Japhari and Emanuel L. Peter
    Citation: Malaria Journal 2025 24:140
    Content type: Review Published on:

  15. Malaria poses a global threat to human health. It’s a vector-borne disease of public health concern and affects the socio-economic status of people in developing countries. Malaria management faces many challe...

    Authors: Alex Muthengi, Alice Karithi, Fidelis Ngugi and Joseph Kiambi Mworia
    Citation: Malaria Journal 2025 24:137
    Content type: Research Published on:

  16. Individuals experiencing recurrent malaria infections encounter a variety of alleles with each new infection. This ongoing allelic diversity influences the development of naturally acquired immunity and it can...

    Authors: Reuben M. Yaa, Kelvin M. Kimenyi, Henry Antonio Palasciano, George Obiero and L. Isabella Ochola-Oyier
    Citation: Malaria Journal 2025 24:136
    Content type: Research Published on:

  17. Ghana adopted the WHO-recommended Seasonal Malaria Chemoprevention (SMC) in 2016 following a pilot study as a vital strategy for malaria control. SMC is the intermittent administration of a preventive and cura...

    Authors: Emmanuel Yidana Ayamba, Emmanuel Kofi Dzotsi, William Dormechele, Nana Akosua Ansah, Oscar Bangre, Josephat Ana-Imwine Nyuzaghl, Sydney Ageyomah Abilba, Samuel Kwabena Boakye-Boateng and Patrick Odum Ansah
    Citation: Malaria Journal 2025 24:123
    Content type: Research Published on:

  18. Mathematical modelling plays a crucial role in understanding malaria epidemiology and evaluating anti-malarial interventions. In sub-Saharan Africa, National Malaria Control Programs are increasingly collabora...

    Authors: Chijioke Kaduru, Uche Ibe, Shina Aladeshawe, Adaeze Eche-George, Ganiyat Eshikhena, Dumale Aadum, Bassey Okon, Emmanuel D. Iorkase, Kesiye Leghemo, Oladipo Ogunbode, Chukwu Okoronkwo, Onyebuchi Okoro, Ehimario U. Igumbor, Abisoye Oyeyemi, Perpetua Uhomoibhi and Seye Babatunde
    Citation: Malaria Journal 2025 24:116
    Content type: Review Published on:

  19. This work investigated the future (2021–2050) impact of Climate Change on Malaria Prevalence in the Upper River Region of The Gambia under two representative concentration pathways, RCP4.5 and RCP8.5, comparin...

    Authors: Ugochinyere Agatha Okafor, Pierre-Claver Konin Kakou, Umberto D’Alessandro, Vincent Nduka Ojeh and Sidat Yaffa
    Citation: Malaria Journal 2025 24:108
    Content type: Research Published on:

  20. Forest-exposed populations remain the last significant, and most difficult to access, high-risk populations for malaria in Cambodia. Despite the availability of long-lasting insecticidal nets (LLINs) and/or ha...

    Authors: David J. McIver, Elodie A. Vajda, Dyna Doum, Nicholas W. Daniel, Molly Quan, Diane D. Lovin, Joanne M. Cunningham, Siv Sovannaroth, Allison Tatarsky and Neil F. Lobo
    Citation: Malaria Journal 2025 24:96
    Content type: Research Published on:

  21. Strengthening malaria control and expediting progress toward elimination requires targeting gametocytes to interrupt transmission. Artemisinin-based combination therapy (ACT) effectively clears Plasmodium falcipa...

    Authors: Kassahun Habtamu, Hallelujah Getachew, Ashenafi Abossie, Assalif Demissew, Arega Tsegaye, Teshome Degefa, Daibin Zhong, Xiaoming Wang, Ming-Chieh Lee, Guofa Zhou, Solomon Kibret, Christopher L. King, James W. Kazura, Beyene Petros, Delenasaw Yewhalaw and Guiyun Yan
    Citation: Malaria Journal 2025 24:87
    Content type: Research Published on:

  22. Assessing the acceptability of new malaria control interventions in clinical trials can be complex due to the need for strict ethical standards and specific trial procedures. While in-depth interviews and focu...

    Authors: Truphena Onyango, Khadija Nuru, Karisa Kazungu, Winnie Wangari, Carlos Chaccour, N. Regina Rabinovich, Joseph Mwangangi, Marta Maia and Caroline Jones
    Citation: Malaria Journal 2025 24:79
    Content type: Research Published on:

  23. Foreign migrant workers from malaria-endemic regions play a critical factor in the transmission of malaria to non-endemic areas, mainly due to their mobility while seeking employment opportunities. This risk i...

    Authors: Nurhadi Eko Firmansyah, Thaksaporn Thongseesuksai, Thidarut Boonmars and Porntip Laummaunwai
    Citation: Malaria Journal 2025 24:18
    Content type: Research Published on:

  24. The increased occurrence of malaria among Africa’s displaced communities poses a new humanitarian problem. Understanding malaria epidemiology among the displaced population in African refugee camps is a vital ...

    Authors: Habtu Debash, Ermiyas Alemayehu, Melaku Ashagrie Belete, Hussen Ebrahim, Ousman Mohammed, Daniel Gebretsadik, Mihret Tilahun and Alemu Gedefie
    Citation: Malaria Journal 2025 24:15
    Content type: Research Published on:

  25. Malaria remains a significant global health challenge, with nearly half of the world's population at risk of infection. In 2022 alone, malaria claimed approximately 608,000 lives, with 76% of these fatalities ...

    Authors: Olivier Sibomana, John Bukuru, Sulymon A. Saka, Marie Grace Uwizeyimana, Alex Mwangi Kihunyu, Abraham Obianke, Samuel Oluwo Damilare, Lewis Tem Bueh, Beloved of God Agbelemoge and Richard Omoefe Oveh
    Citation: Malaria Journal 2025 24:1
    Content type: Review Published on:

  26. Ethiopia has been progressing very well in controlling malaria in the past few years. However, shortly after the COVID-19 pandemic, an unpredictable malaria resurgence was observed in almost all malaria-endemi...

    Authors: Aster Alemu, Beshada Lemma, Temesgen Bekele, Geleta Geshere, Eba Alemayehu Simma, Chernet Tuge Deressa and Tsige Ketema
    Citation: Malaria Journal 2024 23:397
    Content type: Research Published on:

  27. Malaria remains a significant public health concern, despite global efforts to combat the disease with highest burden in Africa. Reports of emerging artemisinin partial- resistance in East Africa emphasize the...

    Authors: Paulina Tindana, Daniel Enos Sekwo, Leonard Baatiema and Abdoulaye Djimde
    Citation: Malaria Journal 2024 23:385
    Content type: Research Published on:

  28. Larval source management (LSM) effectively reduces mosquito populations at their breeding sites, addressing issues like insecticide resistance that limit the effectiveness of primary interventions such as inse...

    Authors: Najat F. Kahamba, Felista S. Tarimo, Khamisi Kifungo, Winifrida Mponzi, Siaba A. Kinunda, Alfred Simfukwe, Salum Mapua, Betwel Msugupakulya, Francesco Baldini, Heather M. Ferguson, Fredros O. Okumu and Marceline F. Finda
    Citation: Malaria Journal 2024 23:336
    Content type: Research Published on:

  29. In 2021, an estimated 750,000 people died from malaria. Despite this significant burden, globally, malaria incidence and mortality rates have substantially dropped over the last 30 years. However, growth in sp...

    Authors: Angela E. Apeagyei, Ian Cogswell, Nishali K. Patel, Kevin O’Rourke, Golsum Tsakalos and Joseph L. Dieleman
    Citation: Malaria Journal 2024 23:333
    Content type: Research Published on:

  30. Malaria remains a significant global health challenge, with millions of cases and high mortality rates annually, especially in low-income countries. Africa bears a substantial burden, with direct costs of mala...

    Authors: Stanley Eneh, Francisca Onukansi, Ogechi Ikhuoria and Temitope Ojo
    Citation: Malaria Journal 2024 23:325
    Content type: Perspective Published on:

  31. Malaria is an infectious disease caused by the Plasmodium species and is a global burden. When not treated correctly, it can reemerge as a relapse or recrudescence. Malaria relapse cases can contribute to maintai...

    Authors: Klauss Kleydmann Sabino Garcia, Karina Medeiros de Deus Henriques, Antonio Alcirley da Silva Balieiro, Anielle de Pina-Costa and André M. Siqueira
    Citation: Malaria Journal 2024 23:312
    Content type: Research Published on:

  32. Healthcare providers (HCPs) practice and correct management of suspected malaria (CMSM) are central components of malaria elimination and prevention of re-establishment (POR) in countries in the elimination ph...

    Authors: Reza Majdzadeh, Mohammad Ali Mansournia, Ayat Ahmadi, Ahmad Raeisi and Hosein Azizi
    Citation: Malaria Journal 2024 23:307
    Content type: Research Published on:

  34. The emergence of Plasmodium falciparum drug resistance against artemisinin-based combination therapy has threatened malaria control efforts. Since malaria control and elimination plans are dependent on these drug...

    Authors: Dagmawi Woldesenbet, Meseret Birhanie, Aberham Abere, Ayalew Jejaw Zeleke, Migbaru Keffale Bezabih, Muluken Semaw, Menberu Wubetie, Wagaw Abebe, Elias Tamene and Yalewayker Tegegne
    Citation: Malaria Journal 2024 23:266
    Content type: Research Published on:

  36. Nigeria has the highest malaria burden globally, and anti-malarials have been commonly used to treat malaria without parasitological confirmation. In 2012, Nigeria implemented rapid diagnostic tests (RDTs) to ...

    Authors: Sandra C. Olisakwe, Julie Thwing, Jodie A. Dionne, Ryan Irvin, Patrick S. Kachur and Katia J. Bruxvoort
    Citation: Malaria Journal 2024 23:249
    Content type: Research Published on:

  37. Ghana is a malaria-endemic country with the entire population at risk. The Northern region of the country recorded the highest malaria case fatality rate (CFR) for two consecutive years: 1.11% in 2013 and 1.07...

    Authors: Nana Yaw Peprah, Wahjib Mohammed, George Asumah Adu, Dora Dadzie, Sammy Oppong, Seidu Barikisu, Joel Narh, Stephen Appiah, James Frimpong and Keziah L. Malm
    Citation: Malaria Journal 2024 23:230
    Content type: Research Published on:

  38. Biological control is a promising alternative or complementary approach for controlling vector populations in response to the spread of insecticide resistance in malaria vectors. This study evaluated the effic...

    Authors: Herieth H. Mahenge, Letus L. Muyaga, Joel D. Nkya, Andrew D. Kafwenji, Yohana A. Mwalugelo, Najat F. Kahamba, Halfan S. Ngowo and Emmanuel W. Kaindoa
    Citation: Malaria Journal 2024 23:228
    Content type: Research Published on:

  39. Thailand aimed to eliminate malaria by 2024, and as such is planning for future prevention of re-establishment in malaria free provinces. Understanding the receptivity of local areas to malaria allows the appr...

    Authors: Rebecca Walshe, Kulchada Pongsoipetch, Suwanna Mukem, Tanong Kamsri, Navarat Singkham, Prayuth Sudathip, Suravadee Kitchakarn, Rapeephan Rattanawongnara Maude and Richard James Maude
    Citation: Malaria Journal 2024 23:224
    Content type: Research Published on:

  40. Malaria remains a global health challenge, particularly in Peru's Loreto region. Despite ongoing efforts, high infection rates and asymptomatic cases perpetuate transmission. The Peruvian Ministry of Health’s ...

    Authors: Viviana Pinedo-Cancino, Katty M. Arista, G. Christian Baldeviano, Rafael Saavedra-Langer, Andrei Arana, Maria E. Vásquez-Chasnamote, Andree Valle-Campos, Juan C. Castro, Julio A. Ventocilla, Edward S. Smith, Andres G. Lescano and Lastenia Ruíz-Mesia
    Citation: Malaria Journal 2024 23:209
    Content type: Research Published on:

  41. While substantial gains have been made in the fight against malaria over the past 20 years, malaria morbidity and mortality are marked by inequality. The equitable elimination of malaria within countries will ...

    Authors: Angela E. Apeagyei, Nishali K. Patel, Ian Cogswell, Kevin O’Rourke, Golsum Tsakalos and Joseph Dieleman
    Citation: Malaria Journal 2024 23:206
    Content type: Research Published on:

    The Publisher Correction to this article has been published in Malaria Journal 2024 23:248

  42. Malaria remains a severe parasitic disease, posing a significant threat to public health and hindering economic development in sub-Saharan Africa. Ethiopia, a malaria endemic country, is facing a resurgence of...

    Authors: Beka R. Abagero, Rei Rama, Abdulghani Obeid, Tirusew Tolosa, Biniyam Lukas, Taye Teka, Daniel Tesfaye, Eugenia Lo and Delenasaw Yewhalaw
    Citation: Malaria Journal 2024 23:194
    Content type: Research Published on:

  44. With only one 15 mg primaquine tablet registered by a stringent regulatory authority and marketed, more quality-assured primaquine is needed to meet the demands of malaria elimination.

    Authors: Julie Nguyen Ngoc Pouplin, Thoopmanee Kaendiao, Bilal Ahmad Rahimi, Mayur Soni, Hensi Basopia, Darshana Shah, Jitendra Patil, Vyom Dholakia, Yash Suthar, Joel Tarning, Mavuto Mukaka and Walter R. Taylor
    Citation: Malaria Journal 2024 23:176
    Content type: Research Published on:

  45. National Malaria Programmes (NMPs) monitor the durability of insecticide-treated nets (ITNs) to inform procurement and replacement decisions. This is crucial for new dual active ingredients (AI) ITNs, for whic...

    Authors: Jacky Raharinjatovo, Roch Kounbobr Dabiré, Keith Esch, Dieudonné Diloma Soma, Aristide Hien, Tiecoura Camara, Mame Birame Diouf, Allison Belemvire, Lilia Gerberg, Taiwo Samson Awolola, Adama Koné, Djenam Jacob, Sophie Vandecandelaere, Marie Baes and Stephen Poyer
    Citation: Malaria Journal 2024 23:173
    Content type: Research Published on:

  46. Mexico has experienced a significant reduction in malaria cases over the past two decades. Certification of localities as malaria-free areas (MFAs) has been proposed as a steppingstone before elimination is ac...

    Authors: Denis Escobar, Gabriela González-Olvera, Ángel S. Gómez-Rivera, Juan Navarrete-Carballo, Pedro Mis-Ávila, Raquel Baack-Valle, Guillermo Escalante, Gerardo Reyes-Cabrera, Fabian Correa-Morales, Azael Che-Mendoza, Gonzalo Vazquez-Prokopec, Audrey Lenhart and Pablo Manrique-Saide
    Citation: Malaria Journal 2024 23:165
    Content type: Research Published on:

  47. Malaria is a major public health concern in Ethiopia, where more than half of the population lives in malaria risk areas. While several studies have been conducted in different eco-epidemiological settings in ...

    Authors: Kinfu Boresa, Tariku Belay, Abdissa Biruksew, Eshetu Alemayehu and Endalew Zemene
    Citation: Malaria Journal 2024 23:152
    Content type: Research Published on:

  48. Despite continuous prevention and control strategies in place, malaria remains a major public health problem in sub-Saharan Africa including Ethiopia. Moreover, prevalence of malaria differs in different geogr...

    Authors: Girma Yutura, Fekadu Massebo, Nigatu Eligo, Abena Kochora and Teklu Wegayehu
    Citation: Malaria Journal 2024 23:143
    Content type: Research Published on:

  49. In 2021 and 2023, the World Health Organization approved RTS,S/AS01 and R21/Matrix M malaria vaccines, respectively, for routine immunization of children in African countries with moderate to high transmission...

    Authors: Beatus M. Lyimo, Catherine Bakari, Zachary R. Popkin-Hall, David J. Giesbrecht, Misago D. Seth, Dativa Pereus, Zulfa I. Shabani, Ramadhan Moshi, Ruth Boniface, Celine I. Mandara, Rashid Madebe, Jonathan J. Juliano, Jeffrey A. Bailey and Deus S. Ishengoma
    Citation: Malaria Journal 2024 23:139
    Content type: Research Published on: