As the prevalence of opioid and polysubstance use during pregnancy continues to rise globally, there is an urgent need to reframe how we support both mothers and infants affected by in utero substance exposure. This issue will spotlight innovative, multidisciplinary care models designed to optimize outcomes for neonates at risk for or diagnosed with Neonatal Abstinence Syndrome (NAS).
A special focus will be placed on integrated care approaches that span the perinatal continuum—from antenatal counseling and addiction support to postnatal management of NAS. Co-located and collaborative services involving obstetricians, addiction medicine specialists, neonatologists, mental health providers, and social workers will be highlighted for their impact on maternal engagement, breastfeeding success, and reduction in NICU length of stay. Models such as "rooming-in" and the Eat, Sleep, Console (ESC) method will be critically examined for their scalability and applicability to the population.
This issue will also explore the long-term growth and neurodevelopmental outcomes infants with prenatal substance exposure, emphasizing the confounding influence of poverty, caregiver instability, and trauma. Attention will be given to the role of early intervention services, predictors of resilience, and the pressing need for standardized follow-up protocols to support optimal cognitive, behavioral, and motor development.
By bringing together clinical innovations, public health perspectives, and developmental follow-up strategies, this issue aims to foster a comprehensive understanding of how to promote long-term well-being including optimal growth and neurodevelopmental outcomes for in this uniquely vulnerable population.