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. 1998 Apr 24;280(5363):605-8.
doi: 10.1126/science.280.5363.605.

A distinctive class of integron in the Vibrio cholerae genome

D Mazel  1 , B Dychinco, V A Webb, J Davies
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A distinctive class of integron in the Vibrio cholerae genome

D Mazel et al. Science. .

Abstract

The ability of bacteria to acquire and disseminate heterologous genes has been a major factor in the development of multiple drug resistance. A gene, intI4, was identified that encodes a previously unknown integrase that is associated with a "gene-VCR" organization (VCRs are Vibrio cholerae repeated sequences), similar to that of the well-characterized antibiotic resistance integrons. The similarity was confirmed by IntI1-mediated recombination of a gene-VCR cassette into a class 1 integron. VCR cassettes are found in a number of Vibrio species including a strain of V. metschnikovii isolated in 1888, suggesting that this mechanism of heterologous gene acquisition predated the antibiotic era.

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