Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Aug 25;10(9):1385.
doi: 10.3390/vaccines10091385.

Vaccines against Emerging and Neglected Infectious Diseases: An Overview

Larissa Vuitika  1 , Wasim A Prates-Syed  1   2 , Jaqueline Dinis Queiros Silva  3 , Karin P Crema  1   2 , Nelson Côrtes  1   2 , Aline Lira  1   2 , Julia Beatriz Menuci Lima  1   2 , Niels Olsen Saraiva Camara  1 , Lena F Schimke  1 , Otavio Cabral-Marques  1 , Mohammad Sadraeian  4 , Lorena C S Chaves  5 , Gustavo Cabral-Miranda  1   2
Affiliations
Review

Vaccines against Emerging and Neglected Infectious Diseases: An Overview

Larissa Vuitika et al. Vaccines (Basel). .

Abstract

Neglected Tropical Diseases (NTDs) are a group of diseases that are highly prevalent in tropical and subtropical regions, and closely associated with poverty and marginalized populations. Infectious diseases affect over 1.6 billion people annually, and vaccines are the best prophylactic tool against them. Along with NTDs, emerging and reemerging infectious diseases also threaten global public health, as they can unpredictably result in pandemics. The recent advances in vaccinology allowed the development and licensing of new vaccine platforms that can target and prevent these diseases. In this work, we discuss the advances in vaccinology and some of the difficulties found in the vaccine development pipeline for selected NTDs and emerging and reemerging infectious diseases, including HIV, Dengue, Ebola, Chagas disease, malaria, leishmaniasis, zika, and chikungunya.

Keywords: emerging infectious diseases; neglected diseases; vaccines.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Vaccine generations and different development strategies used nowadays. VLP (Virus-Like Particle); LNP (Nanoparticle).
Figure 2
Figure 2
Line of development time and release of a vaccine: Discovery and description of the etiological agent; Development of the vaccine prototype; Preclinical tests in animal models; Clinical trials that are subdivided into phase I, phase II, and phase III; Approval, vaccination release, and phase IV clinical test; Mass vaccination program.
Figure 3
Figure 3
Public policies need to ensure vaccination to populations in high-risk areas where nature and social problems, such as war, violence, and poverty, make access difficult by healthcare. They also need to address special groups, including women, the poor, indigenous communities, and patients with comorbidities. However, this cannot be accomplished only by offering vaccines to the population; individuals and communities also need to understand the benefits of vaccination, which will only be accomplished by education.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. WHO Control of Neglected Tropical Diseases. 2022. [(accessed on 20 June 2022)]. Available online: https://www.who.int/teams/control-of-neglected-tropical-diseases.
    1. Engels D., Zhou X.N. Neglected Tropical Diseases: An Effective Global Response to Local Poverty-Related Disease Priorities. Infect. Dis. Poverty. 2020;9:10. doi: 10.1186/s40249-020-0630-9. - DOI - PMC - PubMed
    1. Chami G.F., Bundy D.A.P. More Medicines Alone Cannot Ensure the Treatment of Neglected Tropical Diseases. Lancet Infect. Dis. 2019;19:e330–e336. doi: 10.1016/S1473-3099(19)30160-4. - DOI - PubMed
    1. Reed S.L., McKerrow J.H. Why Funding for Neglected Tropical Diseases Should Be a Global Priority. Clin. Infect. Dis. 2018;67:323–326. doi: 10.1093/cid/ciy349. - DOI - PubMed
    1. Nii-Trebi N.I. Emerging and Neglected Infectious Diseases: Insights, Advances, and Challenges. Biomed Res. Int. 2017;2017:5245021. doi: 10.1155/2017/5245021. - DOI - PMC - PubMed

LinkOut - more resources