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Review
. 2016 Dec;63(10):560-568.
doi: 10.1016/j.endonu.2016.07.008. Epub 2016 Sep 12.

Gut microbiota and type 2 diabetes mellitus

[Article in English, Spanish]
Araceli Muñoz-Garach  1 , Cristina Diaz-Perdigones  1 , Francisco J Tinahones  2
Affiliations
Review

Gut microbiota and type 2 diabetes mellitus

[Article in English, Spanish]
Araceli Muñoz-Garach et al. Endocrinol Nutr. 2016 Dec.

Erratum in

  • Erratum to:"Microbiota y diabetes mellitus tipo 2".
    Muñoz-Garach A, Diaz-Perdigones C, Tinahones FJ. Muñoz-Garach A, et al. Endocrinol Diabetes Nutr. 2017 Nov;64(9):514. doi: 10.1016/j.endinu.2017.08.001. Epub 2017 Sep 21. Endocrinol Diabetes Nutr. 2017. PMID: 29050710 English, Spanish. No abstract available.

Abstract

In recent years, many studies have related gut microbiome to development of highly prevalent diseases such as type 2 diabetes and obesity. Obesity itself is associated to changes in the composition of gut microbiome, with a trend to an overgrowth of microorganisms more efficiently obtaining energy from diet. There are several mechanisms that relate microbiota to the onset of insulin resistance and diabetes, including changes in bowel permeability, endotoxemia, interaction with bile acids, changes in the proportion of brown adipose tissue, and effects associated to use of drugs like metformin. Currently, use of pro and prebiotics and other new techniques such as gut microbiota transplant, or even antibiotic therapy, has been postulated to be useful tools to modulate the development of obesity and insulin resistance through the diet.

Keywords: Diabetes tipo 2; Insulin resistance; Insulinorresistencia; Microbiota; Obesidad; Obesity; Type 2 diabetes.

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