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Safety and Efficacy of Cisplatin and Doxorubicin Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) in Patients with Ovarian Cancer with Peritoneal Metastases: A Multicenter US Phase I Trial
BackgroundPressurized intraperitoneal aerosolized chemotherapy (PIPAC) is a novel, minimally invasive method of delivering intraperitoneal...
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Oncolytic Virotherapy in Solid Tumors: A Current Review
Oncolytic viruses (OVs) are naturally occurring or genetically modified viruses that selectively target cancer cells for infection, replication, and...
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Consensus Guideline for the Management of Gastric Cancer with Synchronous Peritoneal Metastases
BackgroundGastric cancer with synchronous peritoneal metastases (GCPM) is a debilitating disease with limited treatment options. This manuscript...
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D2 Lymphadenectomy for Gastric Cancer: Advancements and Technical Considerations
Lymphadenectomy (LND) is a crucial component of the curative surgical treatment of gastric cancer (GC). The LND serves to both accurately stage the...
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When Benchmarks Fail Us: A Case Study in Cytoreductive Surgery
IntroductionRelative Value Units (RVUs) are utilized to measure physician work effort and create national benchmarks. Physicians are often measured...
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Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC): ChemoAblation for Peritoneal Tumors
Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a novel way to deliver chemotherapy for peritoneal metastases originating from various...
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Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting
Chimeric antigen receptor (CAR) T cell therapeutic responses are hampered by limited T cell trafficking, persistence, and durable anti-tumor activity...
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Safety and Efficacy of Oxaliplatin Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) in Colorectal and Appendiceal Cancer with Peritoneal Metastases: Results of a Multicenter Phase I Trial in the USA
BackgroundPressurized intraperitoneal aerosolized chemotherapy (PIPAC) is a laparoscopic locoregional treatment for peritoneal metastases (PM) from...
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Different Methods of Minimally Invasive Esophagojejunostomy After Total Gastrectomy for Gastric Cancer: Outcomes from Two Experienced Centers
BackgroundEsophagojejunostomy after minimally invasive total gastrectomy (MITG) for gastric cancer (GC) is technically challenging. Failure of the...
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International Delphi consensus guidelines for follow-up after prophylactic total gastrectomy: the Life after Prophylactic Total Gastrectomy (LAP-TG) study
BackgroundProphylactic total gastrectomy (PTG) remains the only means of preventing gastric cancer for people with genetic mutations predisposing to...
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PIPAC for the Treatment of Gynecologic and Gastrointestinal Peritoneal Metastases: Technical and Logistic Considerations of a Phase 1 Trial
BackgroundPeritoneal metastases (PM) from ovarian, gastric, appendiceal, or colorectal origin can be treated via cytoreductive surgery with or...
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CF33-hNIS-antiPDL1 virus primes pancreatic ductal adenocarcinoma for enhanced anti-PD-L1 therapy
Immunotherapeutic strategies that combine oncolytic virus (OV) and immune checkpoint inhibitors have the potential to overcome treatment resistance...
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Gastrectomy for stage IV gastric cancer: a comparison of different treatment strategies from the SEER database
In the West, more than one third of newly diagnosed subjects show metastatic disease in gastric cancer (mGC) with few care options available....
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Single-cell transcriptome analysis of tumor and stromal compartments of pancreatic ductal adenocarcinoma primary tumors and metastatic lesions
BackgroundSolid tumors such as pancreatic ductal adenocarcinoma (PDAC) comprise not just tumor cells but also a microenvironment with which the tumor...
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Impact of Neoadjuvant Therapy on Minimally Invasive Surgical Outcomes in Advanced Gastric Cancer: An International Propensity Score-Matched Study
BackgroundNo international consensus on the treatment of advanced gastric cancer (AGC) exists. In the absence of well-designed, comparative studies...
