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Meso–macroporous hydrogel for direct litre-scale isolation of extracellular vesicles
Extracellular vesicles are cell-originated lipid bilayer membrane vesicles that play vital roles in cell-to-cell communications. While extracellular...
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Zanidatamab monotherapy or combined with chemotherapy in HER2-expressing gastroesophageal adenocarcinoma: a phase 1 trial
There is a need for novel therapies for patients with previously treated HER2-positive gastroesophageal adenocarcinoma (GEA). This phase 1...
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Microfluidic high-throughput 3D cell culture
High-throughput 3D microfluidic cell culture systems can be designed to model aspects of human tissues and organs and may thus serve as non-clinical...
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Favorable clinical efficacy of cytotoxic chemotherapy in patients with progressive desmoid tumors: a retrospective real-world study
BackgroundThe real-world evidence about the efficacy of cytotoxic chemotherapy in desmoid tumors is still limited. We investigated the efficacy of...
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Clinically conserved genomic subtypes of gastric adenocarcinoma
Gastric adenocarcinoma (GAC) is a lethal disease characterized by genomic and clinical heterogeneity. By integrating 8 previously established genomic...
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ESRP1-regulated isoform switching of LRRFIP2 determines metastasis of gastric cancer
Although accumulating evidence indicates that alternative splicing is aberrantly altered in many cancers, the functional mechanism remains to be...
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Determining Which Patients Require Preoperative Pelvic Radiotherapy Before Curative-Intent Surgery and/or Ablation for Metastatic Rectal Cancer
BackgroundThe aim of this study is to determine the optimal indications for preoperative pelvic radiotherapy (RT) in patients with metastatic rectal...
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Hepatocellular carcinoma patients with high circulating cytotoxic T cells and intra-tumoral immune signature benefit from pembrolizumab: results from a single-arm phase 2 trial
BackgroundA limited number of studies have characterized genomic properties of hepatocellular carcinoma (HCC) patients in response to anti-PD-1...
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The prevalence of homologous recombination deficiency (HRD) in various solid tumors and the role of HRD as a single biomarker to immune checkpoint inhibitors
PurposeHomologous recombination deficiency (HRD) is related to tumorigenesis. Currently, the possibility of HRD as a prognostic biomarker to immune...
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Microsatellite Instability and Effectiveness of Adjuvant Treatment in pT1N1 Gastric Cancer: A Multicohort Study
BackgroundMicrosatellite status is a prognostic biomarker in advanced gastric cancer. This retrospective study aimed to investigate the usefulness of...
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A phase I study of IMC-001, a PD-L1 blocker, in patients with metastatic or locally advanced solid tumors
Introduction IMC-001 is a fully human IgG1 monoclonal antibody that binds to human PD-L1 (programmed death-ligand 1).This study evaluated the...
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Prediction of epithelial-to-mesenchymal transition molecular subtype using CT in gastric cancer
ObjectivesTo develop a prediction model with computed tomography (CT) images and to build a nomogram incorporating known clinicopathologic variables...
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ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma
Although RAF monomer inhibitors (type I.5, BRAF(V600)) are clinically approved for the treatment of BRAF V600 -mutant melanoma, they are ineffective in...
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Chromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer
Although tumor genomic profiling has identified small subsets of gastric cancer (GC) patients with clinical benefit from anti-PD-1 treatment, not all...
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Comprehensive molecular characterization of gastric cancer patients from phase II second-line ramucirumab plus paclitaxel therapy trial
BackgroundGastric cancer (GC) is a heterogenous disease consisted of several subtypes with distinct molecular traits. The clinical implication of...
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Tumor-promoting macrophages prevail in malignant ascites of advanced gastric cancer
Gastric cancer (GC) patients develop malignant ascites as the disease progresses owing to peritoneal metastasis. GC patients with malignant ascites...
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Incorporating sarcopenia and inflammation with radiation therapy in patients with hepatocellular carcinoma treated with nivolumab
BackgroundWe investigated the combined effects of sarcopenia and inflammation on outcomes in patients with HCC treated with nivolumab.
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