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Segmentation aware probabilistic phenotyping of single-cell spatial protein expression data
Spatial protein expression technologies can map cellular content and organization by simultaneously quantifying the expression of >40 proteins at...
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T Cell Development: From T-Lineage Specification to Intrathymic Maturation
T cell development occurs in the thymus in both miceMouse and humans. Upon entry into the thymus, bone marrowBone marrow-derived blood-borne...
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Single-cell atlas of the human brain vasculature across development, adulthood and disease
A broad range of brain pathologies critically relies on the vasculature, and cerebrovascular disease is a leading cause of death worldwide. However,...
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In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer
How the genetic landscape governs a tumor’s response to immunotherapy remains poorly understood. To assess the immune-modulatory capabilities of 573...
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RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors
T cell specification and commitment require Notch signaling. Although the requirement for Notch signaling during intrathymic T cell development is...
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T-Cell Development: From T-Lineage Specification to Intrathymic Maturation
T-cell development occurs in the thymus in both mice and humans. Upon entry into the thymus, bone marrow-derived blood-borne progenitors receive...
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HEB is required for the specification of fetal IL-17-producing γδ T cells
IL-17-producing γδ T (γδT17) cells are critical components of the innate immune system. However, the gene networks that control their development are...
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NetworkPainter: dynamic intracellular pathway animation in Cytobank
BackgroundHigh-throughput technologies such as flow and mass cytometry have the potential to illuminate cellular networks. However, analyzing the...
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The characteristic direction: a geometrical approach to identify differentially expressed genes
BackgroundIdentifying differentially expressed genes (DEG) is a fundamental step in studies that perform genome wide expression profiling. Typically,...
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Kinetics of Sub-Micron Grain Size Refinement in 9310 Steel
Recent efforts have focused on the development of novel manufacturing processes capable of producing microstructures dominated by sub-micron grains....
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Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
BackgroundSystem-wide profiling of genes and proteins in mammalian cells produce lists of differentially expressed genes/proteins that need to be...
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ChEA2: Gene-Set Libraries from ChIP-X Experiments to Decode the Transcription Regulome
ChIP-seq experiments provide a plethora of data regarding transcription regulation in mammalian cells. Integrating ChIP-seq studies into a computable...
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Deformation Characteristics and Recrystallization Response of a 9310 Steel Alloy
The flow behavior and recrystallization response of a 9310 steel alloy deformed in the ferrite temperature range were studied in this work. Samples...
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A systems approach identifies HIPK2 as a key regulator of kidney fibrosis
Kidney fibrosis is a common process that leads to the progression of various types of kidney disease. We used an integrated computational and...
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Mechanical Properties of Cast Ti-6Al-4V Lattice Block Structures
Ti-6Al-4V lattice block structure panels were fabricated using an aerospace-quality investment casting process. Testing in compression, bending, and...
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Transformation Superplasticity of Cast Titanium and Ti-6Al-4V
Samples of unalloyed titanium and Ti-6Al-4V with a cast, coarse-grain structure were subjected to simultaneous mechanical loading and thermal cycling...
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Competition Policy under Laissez-Faireism: Market Power and its Treatment in Hong Kong
The paper describes the current competition policy framework in Hong Kong: how it came into existence, what business practices are prohibited, and...
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China—EC Economic Relations: Experience and Prospects
This paper attempts to analyse the economic relations between China and the EC since the opening up of China in 1977 in terms of China’s foreign...
