Epigenetics of Stem Cells: From Totipotency to Tissue Stem Cell Properties

Stem cells are fundamental to the development and maintenance of multicellular organisms, due to their unique capacity for sustained self-renewal and their potential to differentiate into the diverse cell types required for tissue formation. Epigenetic mechanisms play an essential role in endowing stem cells with these specialized properties. Specifically, epigenetic marks confer a dynamic and plastic chromatin organization to both pluripotent and tissue-specific stem cells. Furthermore, epigenetic factors participate in the transition to lineage restriction and stabilize commitment to specific cellular fates. Elucidating how epigenetic elements complement and regulate genomic information throughout the lifespan of stem cells will enable the better understanding and optimal exploitation of these remarkable cells for diverse scientific and therapeutic applications.

Topics of interest include, but are not limited to:

- Comparative epigenetic characteristics of stem cells and differentiated cells, whether stem cells are studied in vivo, isolated and cultured, established as cell lines, or artificially engineered. Primordial germ cells will also be considered.

- Functional roles of epigenetic regulation throughout the stem cell lifespan, from maintenance to commitment and the onset of differentiation.

- Modifications of the stem cell epigenome in response to extrinsic signals or environmental cues, and their impacts on development, tissue homeostasis, disease onset, transgenerational inheritance.

- Role and significance of stem cell epigenetics in stem cell-based technologies, such as in vitro differentiation, organoid formation, and regenerative medicine applications.

- Strategies and methodologies to preserve or manipulate the epigenome of stem cells for biotechnology or therapeutic purposes

All submissions in this collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) will be handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (details here). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visit OA funding and support, or email OAfundingpolicy@springernature.com or the Editor-in-Chief.