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Fig. 4 | Molecular Neurobiology

Fig. 4

From: C9orf72-Associated Dipeptide Repeat Expansions Perturb ER-Golgi Vesicular Trafficking, Inducing Golgi Fragmentation and ER Stress, in ALS/FTD

Fig. 4

C9orfORF72 DPRs polyGA and polyGP disrupt omegasome formation. (A) Fluorescent confocal microscopy of GFP-tagged DFCP1 (double FYVE domain-containing protein) and codon-optimised C9orf72 GAx40, GRx40, GPx40 or PRx40 following immunocytochemistry for each DPR. White arrows: omegasomes. Scale bar: 10 µm. (B) Quantification of the proportion of transfected cells with > 15 omegasomes in (B). Mean ± SEM, n = 3; one-way ANOVA followed by post-hoc Tukey test, ***p < 0.001

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