Skip to main content
Springer Nature Link
Log in
Fig. 1 | Molecular Neurobiology

Fig. 1

From: C9orf72-Associated Dipeptide Repeat Expansions Perturb ER-Golgi Vesicular Trafficking, Inducing Golgi Fragmentation and ER Stress, in ALS/FTD

Fig. 1

Expression and cellular localisation of C9orf72 codon-optimised DPRs in Neuro2A cells. (A) Fluorescent confocal microscopy images following immunocytochemistry for C9orf72 DPRs in untransfected cells (UT), cells expressing pcDNA3.1 empty vector (EV), or codon-optimised C9orf72 DPRsx40 for 48 h. Scale bar: 10 µm. Antibodies specific for each DPR were used (polyGA, polyGR, polyGP, or polyPR). (B) Quantification of the percentage of cells with nuclear only, cytoplasmic only, and both nuclear and cytoplasmic localisation, C9orf72 DPRs from the images in (A). Mean ± SEM, n = 3, 100 + cells per group were examined

Back to article page