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A proteotoxic stress response specific to exhausted T cells, governed by AKT signaling and accompanied by increased protein translation, represents a mechanistic vulnerability and a new therapeutic target to improve cancer immunotherapies.
A thin planar disc designed with appropriately patterned cuts transforms itself, due to air flow effects, into an effective parachute exhibiting good positional stability, regardless of its initial orientation.
Enrichment for efferocytic macrophages in the islets of Langerhans promotes the accumulation of anergic-like CD4+ T cells and dampens autoimmune diabetes.
Structural and biochemical studies of the β-barrel-assembly machinery from Flavobacterium johnsoniae reveal a subunit composition and assembly that are distinct from those of the canonical Escherichia coli complex.
Heat recharges enzyme-free DNA circuits, enabling complex logic operations and neural networks to perform multiple computations, offering a universal energy source for molecular machines and advancing autonomous behaviours in artificial chemical systems.
Capsule-specific human monoclonal antibodies are protective against bloodstream infection by Klebsiella pneumoniae sequence type 147 in a mouse model of septicaemia, and could provide a useful strategy against pathogens with antimicrobial resistance.
A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.
A combined sequencing technique assesses 18 patients with high-grade serous ovarian cancer over a multi-year period from diagnosis to recurrence and shows drug resistance typically arises from selective expansion of one or a few clones present at diagnosis.
A two-phase machine-learning-based tool making use of high-throughput experimentation is introduced to examine the connections between chemical and protein sequence space and predict productive biocatalytic reactions among substrate and enzyme pairs.
Breugnathair elgolensis gen. et sp. nov., an early squamate identified from a newly discovered Middle Jurassic skeleton on the Isle of Skye, provides new evidence on the origins of snakes.
A revised ‘Doughnut’ providing a visual assessment of trends in social deprivation and planetary degradation over the past two decades shows more than doubling of global GDP accompanied by accelerating ecological overshoot but only a modest reduction in human deprivation.
