Extended Data Fig. 6: Protein synthesis is upregulated in exhausted T cells in both tumor and chronic LCMV infection models.
From: Proteotoxic stress response drives T cell exhaustion and immune evasion
a, Volcano plots of differentially expressed proteins in P14 T cells from LCMV acute and chronic infections as described in Extended Data Fig. 3c. Proteins belonging to the protein translation (GO:0006412) are colored in red. b, eIF2D and eIF4G3 expression in P14 T cells from LCMV acute and chronic infections (n = 4, multiple t test). Data are presented as box plots displaying the median (center line), 25th and 75th percentiles (bounds of the box), and minimum and maximum values (whiskers). c-d, Flow cytometry histogram and bar plot of 30-min HPG incorporation ex vivo in tumor-infiltrating CD8+ T cell subpopulations from mouse MC38 (c) and MB49 (d) tumors (spleen: n = 4, TIL: n = 7, one-way ANOVA). Data in c and d are presented as mean ± SD.